Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1988-07-25
1991-09-17
Maples, John S.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
536 27, 514 47, A61K 3170, C07H 1916
Patent
active
050493728
ABSTRACT:
Growth of tumor cells in a host is arrested by the generation of elevated blood and plasma levels of adenosine 5'-triphosphate in said host. These elevated levels can be achieved, for instance, by administering adenosine 5'-monophosphate, adenosine 5'-triphosphate, pharmaceutically acceptable salts thereof, or chelates thereof, or radio-nuclides thereof. Weight loss caused by cancer cachexia is substantially inhibited.
REFERENCES:
patent: 4141972 (1979-02-01), Nishino et al.
patent: 4880918 (1989-11-01), Rapaport
Rapaport et al., "Anticancer Activities of Adenine Nucleotides . . . ", Proceeding of Nat. Acad. of Science, U.S.A., May, 1988.
Chemical Abstracts 98:119267F.
Elmaleh, et al., ".sup.99m Tc-Labelled Nucleotides as Tumor-Seeking Radio Diagnostic Agents", in Proc. Natl. Acad. Sci. U.S.A., vol. 81, pp. 918-921 (Feb. 1984).
Chahwala, et al., "Extracellular ATP Induces Ion Fluxes and Inhibits Growth of Friend Erythroleukemia Cells", Journal of Biological Chemistry, vol. 259, No. 22 (Nov. 25, 1984), pp. 13717-13722.
Kerr, et al., "Proc. Natl. acad. Sci.", U.S.A., vol. 75, No. 1, pp. 256-260, Jan. 1978, pppA2'p5'A2'p5'A.
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