Drug – bio-affecting and body treating compositions – Dentifrices
Patent
1990-12-20
1992-03-17
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Dentifrices
424 54, A61K 716, A61K 722
Patent
active
050966995
ABSTRACT:
An anticalculus oral composition, which is preferably a toothpaste or a mouthrinse, includes an effective anticalculus azacycloalkane-2,2-diphosphonic acid or a salt thereof, preferably azacycloheptane-2,2-diphosphonic acid, and a polymeric polycarboxylate, which is preferably a linear copolymer of maleic anhydride and vinyl methyl ether of a molecular weight in the range of about 5,000-2,000,000, preferably about 30,000-1,500,000. The copolymer surprisingly increases the anticalculus effectiveness of the azacycloalkane-2,2-diphosphonic acid or salt thereof in such compositions, even at comparatively low concentrations of both such materials.
Also within the invention is a process for applying such compositions to the teeth, and it has been shown by both in vitro and in vivo testing that significant and repeatable improvements in anticalculus effects are obtained by such processes, compared to control processes in which either of the active components mentioned is employed alone in the described anticalculus oral compositions.
REFERENCES:
patent: 3925456 (1975-12-01), Ploger et al.
patent: 3941772 (1976-03-01), Ploger et al.
patent: 3984543 (1976-10-01), Ploger et al.
patent: 3988443 (1976-10-01), Ploger et al.
patent: 4108961 (1978-08-01), Ploger et al.
patent: 4108962 (1978-08-01), Ploger et al.
Afflitto John J.
Gaffar Abdul
Joziak Marilou T.
Colgate-Palmolive Company
Grill Murray M.
Rose Shep K.
Stone Robert L.
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