Anticalcification treatment for aldehyde-tanned biological tissu

Details Anticalcification treatment for aldehyde-tanned biological tissu Anticalcification treatment for aldehyde-tanned biological tissu

1992-03-13

1995-12-19

McGinty, Douglas J.

Bleaching and dyeing; fluid treatment and chemical modification

Treatment of hides, skins, feathers and animal tissues

Internal tissues

8 9421, 623 1, 623 2, 623 11, 623 12, 623 66, 623901, 128DIG8, C14C 316, C14C 328, A61F 224, A61F 202

Patent

active

054765161

ABSTRACT:
A method of treating aldehyde-tanned biological tissue minimizes in vivo calcification and reduces cytotoxicity without impairing the mechanical strength of the tanned tissue. The method includes the step of treating the aldehyde-tanned biological tissue with at least one liquid polyol having the formula: ##STR1## where R is CH.sub.2 OH or an alkyl group, and R' is H, an alkyl group or an O-acyl where the acyl is C.sub.2 -C.sub.9 or a carboxyalkyl; or ##STR2## where R is H or an alkyl group, and R' is H, an alkyl group, O-alkyl or O-carboxyalkyl. Preferred polyols are propylene glycol, 1,3-propanediol, 2,3-butylene glycol and glycerol, and the polyol is preferably a diol.

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