Antibody which is directed against and inhibits collagen binding

Details Antibody which is directed against and inhibits collagen binding Antibody which is directed against and inhibits collagen binding

1990-08-31

1995-02-21

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 721, 435 79, 436518, 436548, 53038875, 5303896, 5303913, C07K 1528, G01N 33577

Patent

active

053914813

ABSTRACT:
The present invention provides an antibody which specifically forms a complex with and inhibits collagen binding to VLA-1 and methods of using same.

REFERENCES:
patent: 4443427 (1984-04-01), Reinherz et al.
patent: 4816404 (1989-03-01), Suciu-Foca et al.
Goldman, R., et al., VLA-2 is the integrin used as a collagen receptor by leukocytes, Euro. J. Immunol., 22:1109-1114 (1992) (Exhibit B).
Hemler, M. E., et al., Glycoproteins of 210,000 And 130,000 M.W. On Activated T Cells: Cell Distribution And Antigenic Relation To Components On Resting Cells and T Cell Lines. J. Immunol. 1984; 132: 3011-8.
Hemler, M. E., et al., Biochemical Characterization Of VLA-1 And VLA-2. J. Biol. Che. 1985; 260: 15246-52 (Exhibit B).
Hemler, M. E., et al. The VLA Protein Family. J. Biol. Chem. 1987; 262: 3300-09 (Exhibit C).
Hemler et al, J. Clin. Invest., 78, 696-702, 1986.
Saltini et al, Clin. Immunol. Immunopath., 46, 221-233, 1988.
Hafler et al, Clin. Immunol. Immunopath., 37, 163-171, 1985.
Bank et al, Biol. Abstr., 88, 119, 909, 1989.
Nazzaro et al, J. Invest. Dermatol., 95, 60-64, 1990.
Odum et al, Annals of the Rheumatic Diseases, 46, 846-852, 1987.

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