Antibody variable region of a monoclonal antibody against...

Details Antibody variable region of a monoclonal antibody against... Antibody variable region of a monoclonal antibody against...

2007-03-27

2007-03-27

Gambel, Phillip (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C530S387100, C530S387300, C530S388100

Reexamination Certificate

active

11376338

ABSTRACT:
An antibody variable region of a monoclonal antibody specifically binding to human tumor necrosis factor-α contains at least one of a heavy chain variable region and a light chain variable region having specific complementarity determining regions therein. A nucleic acid molecule encoding the same, a recombinant vector containing the nucleic acid molecule, and a cell transformed with the recombinant vector are also provided.

REFERENCES:
Li et al. Biochemistry 2000. 39:6296-6309.
C. Chothia et al., “Conformations of immunoglobulin hypervariable regions”,Nature, vol. 342, Dec. 21-28, 1989, pp. 877-883.
E. Döring et al., “Identification and Characterization of a TNFα Antagonist Derived from a Monoclonal Antibody”,Molecular Immunology, vol. 31, No. 14, 1994, pp. 1059-1067.
Janeway et al., Immunobiology, p. 3.2, Garland Publishing, New York, 1997.
Rudikoff et al., Proc. Natl. Acad. Sci. 79: 1979-1983 (1982).

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