Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds eukaryotic cell or component thereof or substance...
Patent
1997-09-30
2000-07-11
Chan, Christina Y.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds eukaryotic cell or component thereof or substance...
435332, 435810, 435975, 5303871, 5303882, 5303891, A61K 39395, C12N 520, G01N 3353, C07K 1628
Patent
active
060868791
ABSTRACT:
This invention relates to a method for suppressing the cytotoxic activity of mammalian Natural Killer (NK) cells, especially in women experiencing repeated miscarriages. An antibody which binds to an 80 kDa surface protein on the maternal surface of normal term human syncytiotrophoblast (R80K) was discovered. This antibody was also found to bind to Natural Killer (NK) target cells (K562) and inhibit NK killing of this human NK target cell line. A monoclonal antibody (BA11) was raised against K562 cells which was also directed against a monomorphic site on the R80K surface protein of placentae. BA11 was found both to inhibit the attachment of NK cells and killing of both target cells.
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Chaouat Gerard C. P.
Jalali Gholam R.
Mowbray James F.
Chan Christina Y.
Imperial College of Science Technology and Medicone
VanderVegt F. Pierre
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