Antibody to the neural cell adhesion molecule and methods of use

Details Antibody to the neural cell adhesion molecule and methods of use Antibody to the neural cell adhesion molecule and methods of use

1995-03-16

1997-01-07

Knode, Marian C.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

4241781, 424443, 435 7021, 5303871, 5303911, 606228, 606152, A61K 39395, C12P 2104, C07K 1628, A61B 1704

Patent

active

055914322

ABSTRACT:
The present invention provides an anti-N-CAM monoclonal antibody which enhances, rather than inhibits, neurite outgrowth both in vitro and in vivo. The antibody has positive regulatory effects on nerve cells of both the central and peripheral nervous systems, and is useful for enhancing neurite outgrowth in m vitro studies and for improving nerve regeneration and repair in vivo.

REFERENCES:
patent: 4955892 (1990-09-01), Daniloff
L. L. Lanier, et al. "Molecular and Functional Analysis of Human Natural Killer Cell-Associated Neural Cell Adhesion Molecule (N-CAM/CD56)" J. Immunol. 146:4421-4426 (1991).
B. R. Seckel "Enhancement of Peripheral Nerve Regeneration" Muscle & Nerve 13:785-800 (1990).
L. G. Remsen, et al. "Antibodies to the Neural Cell Adhesion Molecule Disrupt Functional Recovery in Injured Nerves" Exp. Neurol. 110:268-273 (1990).
K. J. Tomaselli and L. F. Reichardt "Integrins, Cadherins, and Cell Adhesion Molecules of the Immunoglobuliin Superfamily: Neuronal Receptros That Regulate Axon Growth and Guidance" The Assembly of the Nervous System, Alan R. Liss, Inc., 1989, pp. 81-108.
Kline et al. (1990) Muscle and Nerve 13:843-852.
Seckel et al. (1990) Muscle and Nerve 13:785-800.
Sucall et al. (1990) J. Cell Biol. 111:2089-2096.
Doherty et al (1992) Nature 356:791-793.
Illa et al. (1992) Ann. Neurol. 31:46-52. (Jan. issue).

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