Antibody to the neural cell adhesion molecule and methods of use

Details Antibody to the neural cell adhesion molecule and methods of use Antibody to the neural cell adhesion molecule and methods of use

1996-05-03

1997-07-29

Feisee, Lila

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241521, 4241561, 4241781, 4241431, 5303871, 530839, 606228, 606152, A61K 39395, C07K 1628, A61B 1704, A61B 1708

Patent

active

056519699

ABSTRACT:
The present invention provides an anti-N-CAM monoclonal antibody which enhances, rather than inhibits, neurite outgrowth both in vitro and in vivo. The antibody has positive regulatory effects on nerve cells of both the central and peripheral nervous systems, and is useful for enhancing neurite outgrowth in in vitro studies and for improving nerve regeneration and repair in vivo.

REFERENCES:
patent: 4955892 (1990-09-01), Daniloff
Small S.J. et al. 1990 J Cell Biol 111:2089-2096.
Doherty P. et al. 1992 Nature 356:791-793.
Kline D.G. 1990 Muscle & Nerve 13:843-852.
L. L. Lanier, et al. "Molecular and Functional Analysis of Human Natural Killer Cell-Associated neural Cell Adhesion Molecule (N-CAM/CD56)" J. Immunol. 146:4421-4426 (1991).
B. R. Seckel "Enhancement of Peripheral Nerve Regeneration" Muscle & Nerve 13:785-800 (1990).
L. G. Remsen, et al. "Antibodies to the Neural Cell Adhesion Molecule Disrupt Functional Recovery in Injured Nerves" Exp. Neurol. 110:268-273 (1990).
K. J. Tomaselli and L. F. Reichardt "Integrins, Cadherins, and Cell Adhesion Molecules of the Immunoglobulin Superfamily: Neuronal Receptors That Regulate Axon Growth and Guidance" The Assembly of the Nervous System, Alan R. Liss, Inc., 1989, pp. 81-108.

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