Antibody to the neural cell adhesion molecule and methods of use

Details Antibody to the neural cell adhesion molecule and methods of use Antibody to the neural cell adhesion molecule and methods of use

1996-05-03

1997-09-16

Feisee, Lila

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 72, 435 792, 435960, 4241411, 4241521, 4241561, 4241781, 4241431, 5303871, 530839, 606228, 606152, A61K 39395, C07K 1628, A61B 1704, G01N 3353

Patent

active

056679785

ABSTRACT:
The present invention provides an anti-N-CAM monoclonal antibody which enhances, rather than inhibits, neurite outgrowth both in vitro and in vivo. The antibody has positive regulatory effects on nerve cells of both the central and peripheral nervous systems, and is useful for enhancing neurite outgrowth in in vitro studies and for improving nerve regeneration and repair in vivo.

REFERENCES:
patent: 4955892 (1990-09-01), Daniloff
Small, SJ et al 1990 J. Cel. Biol. 111:2089-2096.
Doherty P. et al 1992 Nature 356: 791-793.
Kline DG 1990 Muscle & Nerve 13:843-852.
L. L. Lanier, et al. "Molecular and Functional Analysis of Human Natural Killer Cell-Associated neural Cell Adhesion Molecule (N-CAM/CD56)" J. Immunol. 146:4421-4426 (1991).
B. R. Seckel "Enhancement of Peripheral Nerve Regneration" Muscle & Nerve 13:785-800 (1990).
L. G. Remsen, et al. "Antibodies to the Neural Cell Adhesion Molecule Disrupt Functional Recovery in Injured Nerves" Exp. Neurol. 110:268-273 (1990).
K. J. Tomaselli and L. F. Reichardt "Integrins, Cadherins, and Cell Adhesion Molecules of the Immunoglobulin Superfamily: Neuronal Receptors That Regulate Axon Growth and Guidance" The Assembly of the Nervous System, Alan R. Liss, Inc., 1989, pp. 81-108.

Affiliated with

Also associated with

Rating

Antibody to the neural cell adhesion molecule and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibody to the neural cell adhesion molecule and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibody to the neural cell adhesion molecule and methods of use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-217400