Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-10-23
2007-10-23
Belyavskyi, Michail (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387300
Reexamination Certificate
active
10320231
ABSTRACT:
The present invention provides human antibodies specific for stem cell factor that contain at least one CDR derived from a combinatorial antibody library. The invention also provides pharmaceutical compositions comprising the antibodies and methods of treating asthma. The invention further provides methods of detecting stem cell factor using the antibodies.
REFERENCES:
patent: 2005/0112698 (2005-05-01), Neben et al.
patent: WO94/11026 (1994-05-01), None
Paul, Fundamental Immunology, (textbook), 1999, Immunoglobulins: Structure and Function, , pp. 37, 43, 58, 59.
Rudikoff et al., Proc Natl Acad Sci USA 1982 vol. 79 p. 1979.
Campbell, et al. “Stem Cell Factor-Induced Airway Hyperreactivity in Allergic and Normal Mice”,Am J. Pathol., vol. 154, pp. 1259-1265, 1999.
Finotto, et al., “Local administration of antisense phosphorothioate oligonucleotides to the c-kit ligand, stem cell factor, suppresses airway inflammation and IL-4 production in a murine model of asthma”,J. Allergy Clin. Immunol., vol. 107, pp. 279-286, 2001.
Knappik, et al., “Fully Synthetic Human Combinatorial Antibody Libraries (HuCAL) Based on Modular Consensus Frameworks and CDRs Randomized with Trinucleotides”,J. Mol. Biol., vol. 296, pp. 57-86, 2000.
Lukacs, et al, “Stem Cell Factor (c-kitLigand) Influences Eosinophil Recruitment and Histamine Levels in Allergic Airway Inflammation”,J. Immunol., vol. 156, pp. 3945-3950, 1996.
Neben Steven
Takeuchi Toshihiko
Tomkinson Adrian
Bayer Corporation
Belyavskyi Michail
DLA Piper (US) LLP
LandOfFree
Antibody to stem cell factor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibody to stem cell factor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibody to stem cell factor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3892343