Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1994-12-20
1998-05-05
Scheiner, Toni R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303882, 5303891, 436547, 436548, C07K 1618
Patent
active
057476527
ABSTRACT:
Using as an immunogen an oligopeptide containing a different portion of the amino acid sequence of isoform SM-1, SM-2 or SM-3 in smooth muscle myosin heavy chains, for example, the C-terminus amino acid sequence, antibodies capable of distinctly recognizing each isoform from other isoforms of the smooth muscle myosin heavy chains can be obtained. The antibodies are useful as reagents for tissue staining and also useful as diagnostic reagents of vascular disturbance or arteriosclerosis.
REFERENCES:
Roitt (1991) "Essential Immunology", Blackwell Scientific Publications, Oxford, pp. 65-68 & 74.
VanRegenmortel et al. (1990) In "Laboratory Techniques in Biochemistry and Molecular Biology", (R. H. Burdon et al, eds), Elsevier, Amsterdam, pp. 11-13.
Nicol et al (1993) J. Nucl. Med. 34(12):2144-2151.
Nagai et al (1989) J. Biol. Chem. 264(17):9734-9737.
Masaki et al (1986), In "Molecular Biology of Muscle Development" (C. Emerson et al, eds.), Alan R. Liss, Inc., N.Y., pp. 323-336.
Eddinger et al. (1988) Biochemistry 27:3807-3811.
Yanagisawa et al. (1987) J. Mol. Biol. 198:143-157.
J. of Biol. Chem., "DNA Cloning of a Myosin Heavy Chain Isoform in Embryonic Smooth Muscle and Its Expression During Vascular Development and in Arteriosclerosis", Kuro-o et al., vol. 266, No. 6, Feb. 25, 1991, pp. 3768-3733.
J. Biol. Chem., "Identification of Two Types of Smooth Muscle Myosin Heavy Chain Isoforms by cDNA Cloning and Immunoblot Analysis", Nagai et al., vol. 264, No. 17, Jun. 15, 1989, pp. 9734-9737.
Ardizzi et al., The Journal of Cell Biology, vol. 105, No. 6 (1987) pp. 2763-2770.
Mohammad et al., The Biochemical Journal, vol. 260, No. 2 (1989) pp. 421-426.
Sartore et al., Eur. J. Biochem., vol. 179, No. 1 (1989) pp. 79-85.
Borrione et al., Eur. J. Biochem., vol. 183, No. 2 (1989) pp. 413-417.
Kuro et al., The Journal of Biological Chemistry, Vo. 264 No. 31 (1989) pp. 18272-18275.
Kato Hirohisa
Kuroo Makoto
Nagai Ryozo
Scheiner Toni R.
Yamasa Shoyu Kabushiki Kaisha
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