Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1998-12-15
1999-10-12
Housel, James C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303871, 530350, C07K 1600, C07K 100
Patent
active
059657111
ABSTRACT:
The present invention provides a human serine protease precursor (HSPP) and polynucleotides which encode HSPP. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HSPP.
REFERENCES:
Zunino, S.J. et al., "RNKP-1, A Novel Natural Killer-Associated Serine Protease Gene cloned From RNK-16 Cytotoxic Lymphocytes," J. Immunol., 144: 2001-2009 (1990) (GI 206689) (GI 206690).
Sayers, T.J. et al., "Purification and Cloning of a Novel Serine Protease, RNK-Tryp-2, from the Granules of a Rat NK Cell Leukemia", J. Immunol., 152: 2289-2297 (1994).
Trapani, J.A. et al., "Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytes", Proc. Natl. Acad. Sci., 85: 6924-6928 (1988).
Caputo, A. et al., "Nucleotide Sequence and Genomic Organization of a Human T Lymphocyte Serine Protease Gene", J. Immunol., 145: 737-744 (1990).
von Heijne, G., "A new method for predicting signal cleavage sites", Nuc. Acid. Res., 14: 4683-4690 (1986).
Caputo, A. et al., (Direct Submission), GenBank Sequence Database (Accession M38193), National Center for Biotechnology Information, National Library of Madicine, Bethesda, Maryland, 20894 (GI 306682) (GI 825611).
Dahl, C.A. et al., Human Genetics, vol. 84, "Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14", pp. 465-470.
Klein, J.L. et al., Tissue Antigens, vol. 35, "Characterization of a novel, human cytotoxid lymphocyte-specific serine protease cDNA clone (CSP-C", pp.220-228.
Haddad, P. et al., International Immunology, vol. 3, "Structure and evolutionalry origin of the human granzyme H gene", pp. 57-66.
Corley Neil C.
Hillman Jennifer L.
Shah Purvi
Devi S.
Housel James C.
Incyte Pharmaceuticals Inc.
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