Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-10-18
1998-12-08
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 795, 435 7021, 4351722, 43524027, 435975, 436518, 436530, 436548, 5303882, 5303913, 935104, 935110, G01N 33543, G01N 33577, C07K 1628
Patent
active
058467467
ABSTRACT:
A monoclonal antibody has been produced that binds to apical cells of human ocular surface and vaginal epithelia. The antigen recognized by this monoclonal antibody is a mucin-like cell surface glycoprotein. The antibody is of diagnostic use in the evaluation of the ocular surface in dry eye patients, and the antigen has therapeutic potential for use in treatment of dry eye disease. In a comparison of dry eye and normal patients the pattern of antibody binding to dry eye ocular surface epithelia has been shown to differ from the binding pattern seen in normal epithelia.
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Grun James L.
Hutzell Paula K.
Schepen's Eye Research Institute, Inc.
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