Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1995-01-31
1998-12-29
Feisee, Lila
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241301, 4241341, 4241431, 4351722, 4353431, 4353432, 53038822, 53038875, A61K 39395, C07K 1600
Patent
active
058537210
ABSTRACT:
The present invention relates to a novel antibody against the IL-12 receptor and a novel combination of anibodies anainst the IL-12 receptor. The novel anti-IL-12 receptor anbody, designated as 2B10, provided in accordance with the present invention binds to the human IL-12 receptor but which is not capable of inhibiting the binding of human IL-12 to the high affinity human IL-12 receptor and is not capable of neutralizing human IL-12 bioactivity by binding to human IL-12 receptor.
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Chua, Anne Expression Cloning of Human IL-12 Receptor Component to gp 130 Apr. 6, 1994 Journal of Immuno. pp. 128-136.
Leonard, JP et al. Prevention of Experimental Autoimmune Encephalomyelitis by AB Against IL-12.
Gately Maurice Kent
Presky David Howard
Wu Chang-you
Feisee Lila
Hoffmann-La Roche Inc.
Johnston George W.
Kass Alan P.
Sun-Hoffman Lin
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