Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-01-27
2000-04-04
MacMillan, Keith D.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 724, 435971, 435973, 435 794, 435 795, 5303896, 53038877, 436518, 436531, 436534, 436 57, 436824, 436501, G01N 33567, G01N 3353, G01N 33566, C07K 1600
Patent
active
060460121
ABSTRACT:
This disclosure relates to novel antibodies specific to the recently discovered receptor to human interleukin 12 (IL-12R). The antibodies to IL-12R, most preferably, the monoclonal antibodies to that protein, are useful in determining the status of the human immune system and as diagnostic reagents or potential therapeutic reagents for conditions involving imbalances in IL-12 levels or cell types sensitive to IL-12 activation.
Further aspects of the disclosure relate to methods of producing and purifying such novel antibodies and hybridoma cell lines capable of their production. Another aspect of the disclosure relates to an immunoprecipitation assay for the detection of solubilized IL-12R which employs, in a preferred embodiment, monoclonal antibodies to the receptor of the present invention covalently bound to Protein G-Sepharose resin.
REFERENCES:
patent: 4578335 (1986-03-01), Urdal et al.
patent: 4707443 (1987-11-01), Nelson et al.
patent: 5225539 (1993-07-01), Winter
patent: 5852176 (1998-12-01), Gubler et al.
Derwent Abstract No. 87-272811/39, (1987).
Derwent Abstract No. 92-249842/30, (1992).
Bird, et al., Science, 242:423-426 (1988).
Chizzonite, et al., J. Immunol., 147:1548 (1991).
Chizzonite, et al., J. Immunol., 148:3117 (1992).
Chizzonite, et al., J. Cell. Biol., 17:73 (1993).
Chua, et al., J. Immunol., 153:128-136 (1994).
Desai, et al., J. Immunol., 148:3125 (1992).
Desai, et al., J. Immunol., 150(8):270A (1993).
Gubler, et al., Proc. Natl. Acad. Sci. USA, 88:4143-4147 (1991).
Huston, et al., Proc. Natl. Acad. Sci. USA, 85:5879-5883 (1988).
King, J. Immunol. Meth., 72:481-488 (1984).
Stern, et al., Proc. Natl. Acad. Sci. USA, 87:6808-6812 (1990).
Wolf, et al., J. Immunol., 146:3074-3081 (1991).
Chizzonite Richard Anthony
Truitt Theresa Patricia
Buchholz Briana C.
Epstein William H.
Hoffmann-La Roche Inc.
Johnston George W.
MacMillan Keith D.
LandOfFree
Antibody to IL-12 receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibody to IL-12 receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibody to IL-12 receptor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-363969