Antibody to human progesterone receptor and diagnostic materials

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 85, 530387, 530413, 530808, 530809, 436501, 436503, 436504, 436513, 436531, 436548, 436800, 436801, 935106, 935108, 935110, G01N 3353, G01N 33577

Patent

active

047420006

ABSTRACT:
Methods and procedures are described for the isolation of human progestin receptors and for the use of human progestin receptors as immunogens in producing both monoclonal and polyclonal antibodies. These antibodies are used for the detection of progestin receptors, such as the progesterone receptor both normal and cancerous tissues.

REFERENCES:
patent: 4433056 (1984-02-01), Baranczuk
patent: 4454232 (1984-06-01), Breglio et al.
patent: 4656142 (1987-04-01), Jaouen et al.
Edwards et al., J. Steroid Biochem., 20(6B) Jun. 1984, p. 1627 Abstract K4.
Logeat et al., Proc. Nat'l. Acad. Sci. USA, 80(21) 1983, 6456-9.
Logeat et al., Biochemistry, 24(4) Feb. 1985, 1029-35.
Sullivan et al., Endocrinology, 119(4) Oct. 1986, 1549-57.
Greene et al., Human Estrogen Receptor DNA, Science 231:1150-54, Mar. 7, 1986.
Greene, G. L., Biochemical Actions of Hormones, vol. XI, Chapter 8, pp. 207-239, Academic Press, 1984.
King et al., Monoclonal Antibodies Localize Oestrogen Receptor in the Nuclei of Target Cells. Nature 307:745-747, Feb. 23, 1984.
Hawkins, R. W., Receptors in the Management of Breast Cancer, British Journal of Hospital Medicine, pp. 160-164, Sep. 1985.
King et al., Comparison of Immunocytochemical and Steroid-Binding Assays for Estrogen Receptor in Human Breast Tumors, Cancer Research 45:293-304, Jan. 1985.
Heubner et al., An Automatic Multidimensional Chromatography System for Purification of Human Uterine Progesterone Receptor and Induction of Polyclonal Antibodies, J. Steroid Biochem. 24(1):207-214, 1986.
Greene, G. L., Gene Regulation by Steroid Hormones II, Chapter 12, pp. 191-200, Ed. A. K. Roy and J. H. Clark, Springer-Verag, NY 1983.
DeSombre et al., Estrogen Receptors, Antibodies and Hormone Dependent Cancer, Hormones and Cancer, p. 121, Alan R. Liss, Inc., New York, NY, 1983.
Nolan et al., A Sensitive Solid-Phase Enzyme Immunoassay for Human Estrogen Receptor, Current Controversies in Breast Cancer, pp. 433-441, University of Texas Press, Austin, TX, 1984.
Ringold, G. M., Steroid Hormone Regulation of Gene Expression, Ann. Rev. Pharmacol. Toxicol. 25:529-66, 1985.
Liao et al., Autoimmune Anti-Androgen-Receptor Antibodies in Human Serum, Proc. Natl. Acad. Sci. USA 82:8345-48, Dec. 1985.
Lippman, M. E., Management of Breast Cancer with Hormones and Drugs, Hospital Practice, pp. 119-127, May 15, 1986.
Welshons et al., Nuclear Localization of Unoccupied Receptors for Glucocorticoids, Estrogens, and Progesterone in GH.sub.3 Cells, Endocrinology 117(5):2140-46, 1985.
DeSombre et al., Steroid Receptors in Breast Cancer, Special Report, The New England Journal of Medicine 301(18):1011-12, Nov. 1, 1979.
DeSombre, E. R., Breast Cancer: Hormone Receptors, Prognosis and Therapy, Clinics in Oncology 1(1):191-212, Mar. 1982.
Clark et al., Progesterone Receptors as a Prognostic Factor in Stage II Breast Cancer, The New England Journal of Medicine 309(22):1343-47, Dec. 1, 1983.
Eisen, H. J., An Antiserum to the Rat Liver Glucocorticoid Receptor, Proc. Natl. Acad. Sci. USA 77(7):3893-97, Jul. 1980.
Coffer et al., Antibodies to Human Myometrial Oestrogen Receptor, Biochemistry International 1(2):126-32, Aug. 21, 1980.
Logeat et al., Antibodies to Rabbit Progesterone Receptor: Crossreaction with Human Receptor, Proc. Natl. Acad. Sci. USA 78(3):1426-30, Mar. 1981.
Renoir et al., Antibodies Against Progesterone Receptor from Chick Oviduct, Eur. J. Biochem 127:81-86, 1982.
Moncharmont et al., Monoclonal Antibodies Against Estrogen Receptor: Interaction with Different Molecular Forms and Functions of the Receptor, Biochemistry 21:6916-21, 1982.
Okret et al., Monoclonal Antibodies Against the Rat Liver Glucocorticoid Receptor, Proc. Natl. Acad. Sci. USA 81:1609-13, Mar. 1984.
Pierce et al., Monoclonal Antibodies to Human Vitamin D-Binding Protein, Proc. Natl. Acad. Sci. USA 82:8429-33, Dec. 1985.
Edwards et al., Structural Analysis of Chicken Oviduct Progesterone Receptor Using Monoclonal Antibodies to the Subunit B Protein, Biochemistry 23:4427-35, 1984.
Sullivan et al., Isolation of Steroid Receptor Binding Protein from Chicken Oviduct and Production of Monoclonal Antibodies, Biochemistry 24(15):4214-22, 1985.
Coffer et al., Immunoradiometric Studies with Monoclonal Antibody Against a Component Related to Human Estrogen Receptor, Cancer Research 45:3694-98, Aug. 1985.
Jensen et al., Basic Guides to the Mechanism of Estrogen Action, Ben May Laboratory of Cancer Research, The University of Chicago, Chicago, Illinois, pp. 387-414.
DeSombre et al., Correlation of ER-ICA with Quantitative ER Assays and Time to Recurrence and Survival in Breast Cancer, AACR Abstract, AACR Annual Meeting, May 22-25, 1985, Houston, TX.
Grandics et al., A New Affinity Resin for Purification of Non-Transformed Avian Progesterone Receptor, Endocrinology 110(3):1055-57, 1982.
Horwitz et al., In situ Photolinked Nuclear Progesterone Receptors of Human Breast Cancer Cells: Subunit Molecular Weights after Transformation and Translocation, Endocrinology 113(6):2195-2201, 1983.
Gormley et al., A Controlled Pore Glass Bead Assay for the Measurement of Cytoplasmic and Nuclear Glucocorticoid Receptors, J Steroid Biochem. 22(6):693-98, 1985.
Luben et al., Monoclonal Antibodies to Hypothalamic Growth Hormone-Releasing Factor with Picomoles of Antigen, Science 218:887-89, Nov. 26, 1982.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antibody to human progesterone receptor and diagnostic materials does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibody to human progesterone receptor and diagnostic materials, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibody to human progesterone receptor and diagnostic materials will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1505877

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.