Antibody therapy

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds expression product or fragment thereof of...

Reexamination Certificate

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C424S130100

Reexamination Certificate

active

08062636

ABSTRACT:
The present invention provides a composition comprising naked humanized, chimeric, and human anti-CEA antibodies and a therapeutic agent, which is useful for treatment of CEA expressing cancers and other diseases, and methods of use in treatment using this composition.

REFERENCES:
patent: 4818709 (1989-04-01), Primus et al.
patent: 4970071 (1990-11-01), McMichael
patent: 5081235 (1992-01-01), Shivery et al.
patent: 5530101 (1996-06-01), Queen et al.
patent: 5843708 (1998-12-01), Hardman et al.
patent: 5874540 (1999-02-01), Hansen et al.
patent: 5877293 (1999-03-01), Adair et al.
patent: 6077499 (2000-06-01), Griffiths et al.
patent: 7011812 (2006-03-01), Griffiths et al.
patent: 2004/0001825 (2004-01-01), Govindan et al.
patent: 2004/0043030 (2004-03-01), Griffiths et al.
patent: 2005/0222392 (2005-10-01), Carter et al.
patent: 2006/0160766 (2006-07-01), Cheung
patent: 0239400 (1987-09-01), None
patent: 0323805 (1989-07-01), None
patent: 0323806 (1989-07-01), None
patent: 91/01990 (1991-02-01), None
patent: 92/01059 (1992-01-01), None
patent: 92/11018 (1992-07-01), None
patent: 95/15769 (1995-06-01), None
patent: 96/01126 (1996-01-01), None
patent: 96/08506 (1996-03-01), None
patent: 96/11013 (1996-04-01), None
Dillman, Journal of Clinical Oncology vol. 12 p. 1497 (1994).
Beckman et al., “Antibody Constructs in Cancer Therapy”, Cancer 109:170-179 (2007).
Begent et al., “Clinical Evidence of Efficient Tumor Targeting Based on Single-Chain Fv Antibody Selected from a Combinatorial Library”, Nat. Med. 2:979-984 (1996).
Berenbaum, M., “Synergy, additivism and antagonism in immunosuppresion”, Clin. exp. Immunol. (1997) 28, 1-18.
Berenbaum, M., “What is Synergy?”, Pharmacol. Rev. 41:93-141 (1989).
Blumenthal et al., “Comparison of Equitoxic Radioimmunotherapy and Chemotherapy in the Treatment of Human Colonic Cancer Xenografts”, Cancer Res., 54:142-151 (1994).
Blumenthal et al., “Targeted therapy of athymic mice bearing GW-39 human colonic cancer micrometastases with 131I-labeled monoclonal antibodies”, Cancer Res. 52(21):6036-44 (1992).
Blumenthal et al., “Carcinoembryonic antigen antibody inhibits lung metastasis and augments chemotherapy in a human colonic carcinoma xenograft”, Cancer Immunol. Immunother. 54(4):315-27 (2005).
Casset et al., “A peptide mimetic of an anti-CD74 monoclonal antibody by rational design”, Biochem. Biophys. Research Comm. 307:198-205 (2003).
Dennis, C. “Off by a Whisker”, Nature 442:739-741 (2006).
Dillman, R., “Antibodies as cytotoxic therapy”, J Clin Oncol. Jul. 1994;12(7):1497-515.
Groninger et al., “Vincristine Induced Apoptosis in Acute Lymphoblastic Leukaemia Cells: A Mitochondrial Controlled Pathway Regulated by Reactive Oxygen Species?” Abstract, Int. J. Oncol. 21:1339-45 (2002).
Hansen et al., “Characterization of Second-Generation Monoclonal Antibodies Against Carcinoembryonic Antigen”, Cancer 71:3478-3485 (1993).
Juweid et al., “Radioimmunotherapy of medullary thyroid cancer with iodine-131-labeled anti-CEA antibodies”, J. Nucl. Med. 37(6):905-11 (1996).
Juweid et al., “Radioimmunotherapy of patients with small-volume tumors using iodine-131-labeled anti-CEA monoclonal antibody NP-4 F(ab')2”, J Nucl Med. 37(9):1504-10 (1996).
Juweid et al., “Phase I/II Trial of 131I-MN-14 F(ab)2 Anti-Carcinoembryonic Antigen Monoclonal Antibody in the Treatment of Patients with Metastatic Medullary Thyroid Carcinoma”, Cancer 85(8):1828-1842 (1999).
Losman et al., “Mimicry of a Carcinoembryonic Antigen Epitope by a Rat Monoclonal Anti-Idiotype Antibody”, Int. J. Cancer 56:580-584 (1994).
MacCallum et al., “Antibody-antigen Interactions: Contact Analysis and Binding Site Topography”, J. Mol. Biol. 262:732-745 (1996).
Mani et al., “Novel Combinations with Oxaliplatin” Abstract, Oncol. 14:52-8 (2000).
Mayer et al., “Radioimmunoguided Surgery in Colorectal Cancer Using a Genetically Engineered Anti-CEA Single-Chain Fv Antibody”, Clin. Can. Res. 6:1711-1719 (2000).
Muyldermans et al., “Sequence and structure of VH Domain from naturally occurring camel heavy chain immunoglobulins lacking light chains”, Protein Eng. 7(9):1129-35 (1994).
Nap et al., “Specificity and Affinity of Monoclonal Antibodies against Carcinoembryonic Antigen”, Can. Res. 52:2329-2339 (1992).
Neumaier et al., “Cloning of the Genes for T84.66, an Antibody that has a High Specificity and Affinity for Carcinoembryonic Antigen, and Expression of Chimeric Human/Mouse T84.66 Genes in Myeloma and Chinese Hamster Ovary Cells”, Can. Res. 50:2128-2134 (1990).
Nowak et al., “Induction of Tumor Cell Apoptosis in Vivo Increases Tumor Antigen Cross-Presentation, Cross-Priming Rather than Cross-Tolerizing Host Tumor-Specific CD8 T Cells”, J. Immunol. 170:4905-13 (2003).
Pascalis et al., “Grafting of “Abbreviated” Complementarity-Determining Regions Containing Specificity-Determining Residues Essential for Ligand Contact to Engineer a Less Immunogenetic Humanized Monoclonal Antibody”, J. Immunol. 169:3076-3084 (2002).
Paul, W. (ed.), Fundamental Immunology, Raven Press, NY, 1993, p. 242.
Perez et al., “A Multivalent Recombinant Antibody Fragment Specific for Carcinoembryonic Antigen”, Biotechnol. Appl. Biochem. 43:39-48 (2006).
Primus et al., “Immunological heterogeneity of carcinoembryonic antigen: antigenic determinants on carcinoembryonic antigen distinguished by monoclonal antibodies”, Cancer Res. 43(2):686-692 (1983).
Queen et al., “A humanized antibody that binds to the interleukin 2 receptor”, Proc. Natl. Acad. Sci. USA 86:10029-10033 (1989).
Ray et al., “Apoptosis Induction of Prostate Cancer Cells and Xenografts by Combined Treatment with Apo2 Ligand/Tumor Necrosis Factor-related Apoptosis-inducing Ligand and CPT-11”, Can. Res. 63:4713-23 (2003).
Riechmann et al., “Reshaping human antibodies for therapy”, Nature 332(6162):323-7 (1988).
Rigas et al., “Selective Induction of Colon Cancer Cell Apoptosis by 5-Flourouracil in Humans”, Abstract, Cancer Invest. 20:657-65 (2002).
Senba et al., “Tumor Growth Suppression by a Mouse/Human Chimeric Anti-CEA Antibody and Lymphokine-Activated Killer Cells in Vitro and in SCID Mouse Xenograft Model”, Anticancer Research 18:17-24 (1998).
Sharkey et al., “Murine Monoclonal Antibodies against Carcinoembryonic Antigen: Immunological, Pharmacokinetic, and Targeting Properties in Humans”, Cancer Res. 50:2823-2831 (1990).
Sharkey et al., “Clinical evaluation of tumor targeting with a high-affinity, anticarcinoembryonic-antigen-specific, murine monoclonal antibody, MN-14”, Cancer 71(6):2082-96 (1993).
Sharkey et al., “Comparison of Tumor Targeting in Nude Mice by Murine Monoclonal Antibodies Directed against Different Human Colorectal Cancer Antigens”, Cancer Res. (Suppl.) 50:828-834 (1990).
Sharkey et al., “Evaluation of a complementarity-determining region-grafted (humanized) anti-carcinoembryonic antigen monoclonal antibody in preclinical and clinical studies”, Cancer Res. 55(23 Suppl):5935s-5945s (1995).
Shibuya et al., “Induction of Apoptosis and/or Necrosis Following Exposure to Antitumour Agents in a Melanoma Cell Line, Probably Through Modulation of Bcl-2 Family Proteins”, Abstract, Melanoma Res. 13:457-64 (2003).
Simoes-Wust et al., “Bcl-2/bcl-xL Bispecific Antisense Treatment Sensitizes Breast Carcinoma Cells to Doxorubicin, Paclitaxel and Cyclophosphamide”, Abstract, Breast Cancer Res. 76:157-66 (2002).
Stein et al., “Combining Radioimmunotherapy and Chemotherapy for Treatment of Medullary Thyroid Carcinoma”, Cancer 94:51-61 (2002).
Stein et al., “A humanized monoclonal antibody to carcinoembryonic antigen, labetuzumab, in

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