Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2011-07-26
2011-07-26
Wen, Sharon (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387100, C530S387300, C530S388100, C424S130100
Reexamination Certificate
active
07985844
ABSTRACT:
Modulation of Hyaluronan (HA) synthesis and degradation is disclosed by compounds and compositions that are capable of reducing the level of hyaluronan synthase (HAS) or hyaluronidase (HYAL) or the function or activity of HAS or HYAL. The compounds and compositions can also inhibit the expression of genetic material encoding these enzymes. The compounds and compositions comprise nucleic acid molecules and interactive molecules such as antibodies, small molecule inhibitors and substrate analogs of HAS and HYAL. The compounds and compositions are useful in the prophylaxis and/or treatment of inflammatory disorders including hyperproliferative conditions, such as but not limited to, cancer and psoriasis.
REFERENCES:
patent: 5994100 (1999-11-01), Zhu et al.
patent: 6682904 (2004-01-01), Frost
patent: 7662929 (2010-02-01), Brown et al.
patent: 2002/0151026 (2002-10-01), Briskin
patent: 2007/0286856 (2007-12-01), Brown et al.
patent: 2009/0068183 (2009-03-01), Brown et al.
patent: 0 881 294 (1998-12-01), None
patent: 2002-293740 (2002-10-01), None
patent: WO-97/40174 (1997-10-01), None
patent: WO-98/00551 (1998-01-01), None
patent: WO-98/00551 (1998-01-01), None
patent: WO-98/00553 (1998-01-01), None
patent: WO-2004/003158 (2004-01-01), None
patent: WO-2004/003158 (2004-01-01), None
patent: WO-2004/082610 (2004-09-01), None
patent: WO-2004/082610 (2004-09-01), None
patent: WO-2005/035548 (2005-04-01), None
patent: WO-2007/112475 (2007-10-01), None
Biosis Database Accession No. PREV200200186712 (Nov. 16, 2001). “Hyaluronan Synthases as Potential Oncogenes in Myeloma,” Abstract only, two pages.
Itano, N. et al. (Apr. 30, 2004). “Selective Expression and Functional Characteristics of Three Mammalian Hyaluronan Synthases in Oncogenic Malignant Transformation,”The Journal of Biological Chemistry279(18):18679-18687.
Bullard, K.M. et al. (2003). “Hyaluronan Synthase-3 Is Regulated in Metastatic Colon Carcinoma Cells and Manipulation of Expression Alters Matrix Retention and Cellular Growth,”Int. J. Cancer107(5):739-746.
Chao, H. et al. (Jul. 29, 2005). “Natural Antisense mRNAs to Hyaluronan Synthase 2 Inhibit Hyaluronan Biosynthesis and Cell Proliferation,”Journal Biological Chemistry280(30):27513- 27522.
Falkenberg, F.W. et al. (1984).J. Clin. Chem. Clin. Biochem.22:867-882.
Final Office Action mailed on Feb. 23, 2009, for U.S. Appl. No. 10/574,903, filed Feb. 28, 2007, seven pages.
Hakanson, E.Y. et al. (1948). “Inhibition of Hyaluronidase by Serum in Human Cancer,” Chemical Abstracts Accession No. 43:15662 &J. Natl. Cancer Inst. 9:129-132. (Abstract Only.).
International Search Report mailed Jan. 7, 2005, for PCT Application No. PCT/AU2004/001383, filed Oct. 11, 2004, four pages.
International Search Report mailed May 30, 2007, for PCT Application No. PCT/AU2007/000359, filed Mar. 23, 2007, three pages.
Nishida, Y. et al. (Jul. 1999). “Antisense Inhibition of Hyaluronan Synthase-2 in Human Articular Chondrocytes Inhibits Proteoglycan Retention and Matrix Assembly,”J. Biological Chem.274(31):21893-21899.
Non-final Office Action mailed on Aug. 19, 2008, for U.S. Appl. No. 10/574,903, filed Feb. 28, 2007, 12 pages.
Owens, R.J. et al. (1994).Journal of Immunological Methods168:149-165.
Simpson, M.A. et al. (Mar. 2002). “Manipulation of Hyaluronan Synthase Expression in Prostate Adenocarcinoma Cells Alters Pericellular Matrix Retention and Adhesion to Bone Marrow Endothelial Cells,”J. Biological Chem.277(12):10050-10057.
Simpson, M.A. et al. (Sep. 2002). “Inhibition of Prostate Tumor Cell Hyaluronan Synthesis Impairs Subcutaneous Growth and Vascularization in Immunocompromised Mice,”Am. J. Pathol.161(3):849-857.
Udabage, L. et al. (2005). “The Over-Expression ofHAS2, Hyal-2and CD44 is Implicated in the Invasiveness of Breast Cancer,”Experimental Cell Research310:205-217.
Udabage, L. et al. (Jul. 15, 2005). “Antisense-Mediated Suppresion of Hyaluronan Synthase 2 Inhibits the Tumorigenesis and Progression of Breast Cancer,”Cancer Research65(14):6139-6150.
Ueki, N. et al. (2000). “Inhibition of Hyaluronan Synthesis by Vesnarinone in Cultured Human Myofibroblasts,”Biochimica et Biophysica Acta1495(2):160-167.
Zhang, W. et al. (2000). “Glucocorticoids Induce a Near-Total Suppression of Hyaluronan Synthase mRNA in Dermal Fibroblasts and in Osteoblasts: a Molecular Mechanism Contributing to Organ Atrophy,”Biochemical J.349(Part 1):91-97.
Brown Tracey J.
Brownlee Gary R.
Alchemia Oncology Pty Limited
Morrison & Foerster / LLP
Wen Sharon
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