Combinatorial chemistry technology: method – library – apparatus – Method of screening a library – By measuring the ability to specifically bind a target...
Reexamination Certificate
2011-07-19
2011-07-19
Wessendorf, T. D. (Department: 1639)
Combinatorial chemistry technology: method, library, apparatus
Method of screening a library
By measuring the ability to specifically bind a target...
C506S026000, C506S023000, C506S007000, C506S001000, C435S007100, C530S387100
Reexamination Certificate
active
07981843
ABSTRACT:
The present invention provides methods of making antibodies having the binding specificity of a reference antibody. Antibodies generated by the methods of the inventions have at least one minimal essential binding specificity determinant from a heavy chain or light chain CDR3 from the reference antibody. The method can be used, e.g., in humanization procedures. The invention also provides libraries and antibodies made in accordance with the methods.
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Balint Robert F.
Bebbington Christopher R.
Flynn Peter
Her Jeng-Horng
Luehrsen Kenneth
KaloBios Pharmaceuticals, Inc.
Kilpatrick Townsend & Stockton
Wessendorf T. D.
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