Antibody specific to central nervous system tau protein

Details Antibody specific to central nervous system tau protein Antibody specific to central nervous system tau protein

2005-02-11

2008-10-28

Shibuya, Mark L (Department: 1641)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007100, C435S007920, C435S007930, C435S007940, C435S007950, C435S962000, C435S975000, C436S503000, C436S518000, C436S536000, C436S547000, C436S063000, C436S174000, C436S175000, C530S388200, C530S389100

Reexamination Certificate

active

07442516

ABSTRACT:
The present invention provides an antibody which specifically recognizes a CNS tau protein but not a peripheral tau protein. More specifically, the present invention provides an antibody obtainable by using a polypeptide comprising an amino acid sequence of a connective portion between the amino acid sequence encoded by Exon 4 of a gene encoding a tau protein and the amino acid sequence encoded by Exon 5 thereof as an epitope specific to the isoform of tau protein predominantly existing in central nervous tissues. The present invention further provides a method of detecting Alzheimer's disease and a reagent kit using the antibody.

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