Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2007-07-17
2007-07-17
Spector, Lorraine (Department: 1646)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C424S138100, C536S023530, C530S387100, C530S388220, C530S388800, C530S350000, C435S334000, C435S344000
Reexamination Certificate
active
10275180
ABSTRACT:
An antibody of the invention interacts with human DR5 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-DR5 antibodies have been elucidated and vectors and cells containing and expressing these sequences have been generated. Methods and uses for the antibodies are detailed including treatment of apoptosis-related disease and treatment of dysregulated cell growth.
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Ichikawa Kimihisa
Kimberly Robert P.
Koopman William J.
Zhou Tong
Fish & Richardson P.C.
Kaufman Claire M.
Spector Lorraine
The UAB Research Foundation
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