Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-07-24
2007-07-24
Rawlings, Stephen L. (Department: 1643)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C530S350000, C530S388700
Reexamination Certificate
active
11007388
ABSTRACT:
The subject invention pertains to antibodies that have binding specificity for an antigen that is expressed on a subset of human, hematopoietic mononuclear cells, including a hematopoietic stem cell population, but is not expressed on normal, mature myeloid cells. In one embodiment, a monoclonal antibody, MG1, is provided. This antibody is useful in methods of isolating cell suspensions from human blood and marrow that can be employed in bone marrow transplantation, genetic therapy, and in treating other diseases of the hematopoietic system. Cell suspensions containing MG1+human hematopoietic cells are also provided, as well as therapeutic methods employing the cell suspensions. The subject invention also pertains to the novel antigen recognized by the subject antibodies.
REFERENCES:
patent: 4714680 (1987-12-01), Civin
patent: 5061620 (1991-10-01), Tsukamoto et al.
patent: 5585089 (1996-12-01), Queen et al.
patent: 6838282 (2005-01-01), Lawman et al.
patent: 0895670 (1983-05-01), None
patent: WO 93/25216 (1993-12-01), None
patent: WO 94/02157 (1994-02-01), None
patent: WO 95/03693 (1995-02-01), None
patent: WO 96/15229 (1996-05-01), None
patent: WO 98/21334 (1998-05-01), None
Skolnick et al. (Trends in Biotechnology. 2000; 18: 34-39).
Greenspan et al. (Nature Biotechnology. 1999; 7: 936-937).
George et al. (Circulation. 1998; 97: 900-906).
Gangenahalli et al. (Stem Cells Dev. Apr. 14, 2005 (2): 140-152.
Yu et al. (J. Biol. Chem. Jun. 7, 2002; 277 (23): pp. 20711-20716).
Zannettino et al. (Blood. Oct. 15, 1998; 92 (8): 2613-2628).
Ramshaw et al. (Exp. Hematol. Aug. 2001; 29 (8): 981-992).
Buhring et al. (Blood. Oct. 1, 1999; 94 (7): 2343-2356).
Shworak et al. (J. Biol. Chem. Oct. 31, 1997; 272 (44): 28008-28019).
Banks et al. (Eur. J. Biochem. 1976; 71: 469-473).
Bodger, M.P. et al. (1981) “A monoclonal antibody specific for immature human hemopoietic cells and T lineage cells”Journal of Immunology, vol. 127, No. 6, pp. 2269-2274.
Ritz, J. et al. (1980) “A monoclonal antibody to human acute lymphoblastic leukaemia antigen”Nature, vol. 283 pp. 583-585.
Civin, C.I. et al. (1984) “Antigenic Analysis of Hematopoiesis III. A Hematopoietic Progenitor Cell Surface Antigen Defined by a Monoclonal Antibody Raised against KG-1a Cells”Journal of Immunology, vol. 133, No. 1, pp. 157-165.
Craig, W. et al. (1993) “Expression of Thy-1 on Human Hematopoietic Progenitor Cells”J. Ex. Med., vol. 177, pp. 1331-1342.
Berenson, R.J. et al. (1988) “Antigen CD34+Marrow Cells Engraft Lethally Irradiated Baboons”J. Clin. Invest., vol. 81, pp. 951-955.
Terstappen, L.W. (1990) “Flow Cytometric Analysis of Human Bone Marrow III. Neutrophil Maturation”Leukemia, vol. 4, No. 9, pp. 657-663.
Loken, M.R. et al. (1987) “Flow Cytometric Analysis of Human Bone Marrow II. Normal B. Lymphocyte Development”Blood, vol. 70, No. 5, pp. 1316-1324.
Friedmann, T. (1989) “Progress Toward Human Gene Therapy”Science, vol. 244, pp. 1275-1281.
Sutherland, H.J. et al. (1991) “Differential Regulation of Primitive Human Hematopoietic Cells In Long-Term Cultures Maintained on Genetically Engineered Murine Stromal Cells”Blood, vol. 78, No. 3, pp. 666-672.
Terstappen, L.W. et al. (1991) “Sequential Generations of Hematopoietic Colonies Derived From Single Nonlineage-Committed CD34+CD38 Progenitor Cells”Blood77(6):1218-1227.
Bender, J.G. et al. (1991) “Identification and Comparison of CD34-Positive Cells and Their Subpopulations From Normal Peripheral Blood and Bone Marrow Using Multicolor Flow Cytometry”Blood, vol. 77, No. 12, pp. 2591-2596.
Terstappen, L.W. et al. (1991) “Sequential Generations of Hematopoietic Colonies Derived From Single Nonlineage-Committed CD34+CD38 Progenitor Cells”Blood, vol. 77, No. 6, pp. 1218-1227.
Loken, M.R. et al. (1987) “Flow Cytometric Analysis of Human Bone Marrow: I. Normal Erythroid Development”Blood, vol. 69, No. 1, pp. 255-263.
Simmons, P.J. et al. “Identification of Stromal Cell Precursors In Human Bone Marrow by a Novel Monoclonal Antibody, STRO-1”Blood(1991), vol. 78, No. 1, pp. 55-62.
Golde, D.W. (1991) “The Stem Cell”Scientific AmericanVol. 265, No. 6, pp. 86-93.
No Authors Listed, “Gene Therapy in Man”,The Lancet(1988), vol. 1, pp. 1271-1272.
Lawman Michael J. P.
Lawman Patricia
Morphogenesis, Inc.
Rawlings Stephen L.
Saliwanchik Lloyd & Saliwanchik
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