Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1988-03-21
1989-06-20
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530388, 530412, 530413, 530808, 435 68, 43524027, 424 858, 935107, 935110, A61K 39395, C07K 312
Patent
active
048410250
ABSTRACT:
A monoclonal antibody preparation having a single binding activity, which activity is in respect of a cell surface antigen, comprises IgG antibody molecules in which only one of the two light chains will bind to said antigen, the proportion of such antibody molecules being enhanced relative to IgG antibody molecules having two light chains which will bind to said antigen to thereby produce an enhancement of the binding activity of the preparation. Such preparations containing predominatly "monovalent antibodies" are of particular value in the areas of transplantation immunity, the treatment of neoplastic disease and cell sorting.
REFERENCES:
Galfre et al., Nature, 277 (1979), 131-3.
Peabody, Ely, and Edmundson, Biochemistry, 1980, 19, 2827-2834.
U. Raso and T. Griffin, Cancer Research, 1981, 2073-2076.
S. P. Cobbold & H. Waldmann, Therapeutic Potential of Monovalent Monoclonal Antibodies, Nature, 1984, vol. 308, No. 5958, pp. 460-462.
M. J. Glennie & G. T. Stevenson, Univalent Antibodies Kill Tumour Cells in Vitro and in Vivo, Nature, vol. 295, Feb. 1982, p. 712.
G. T. Stevenson, M. J. Glennie, J. Gordon, The Killing of Lymphoma Cells by Univalent Derivatives of Tumor--Specific Antibody, B & T Cells Tumor, 1982, p. 459.
G. T. Stevenson and D. Straus, Specific Dimerization of the Light Chains of Human Immunoglobulin, Biochemical Journal, 1984, p. 375.
Cobbold Stephen P.
Waldmann Herman
National Research Development Corporation
Nucker Christine M.
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