Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1984-07-02
1987-02-17
Rosen, Sam
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
436543, G01N 3353
Patent
active
046439676
ABSTRACT:
A method and apparatus for reducing the risk of occurrence in human offspring of diseases in which the susceptibility of the individual is known to be linked to the gene complex encoding the human leukocyte antigens (HLA). Antibody molecules specific for an HLA antigen having a known disease association are used to deplete native semen samples with respect to spermatozoa bearing the targeted HLA antigen on their surface membranes while leaving unaffected, and suitable for fertilization, other spermatozoa in the sample which lack the disease-associated HLA antigen. The specific depletion is effected by cellular killing or inhibition of motility through linkage of the HLA antibody bound by spermatozoa to a cytotoxic molecule such as complement.
REFERENCES:
patent: 4191749 (1980-03-01), Bryant
Dausset--Science vol. 213 Sep. 25, 1981 pp. 1469-1474.
A. Svejgaard--Transplantation Proceed, vol. 13 (1981) p. 914.
Anderson et al.--J. of Immunol. vol. 129 (1982) pp. 452-454.
Isojima et al.--Chem. Abst. vol. 97 (1982) pp. 142,832 z.
Bloom Leonard
Rosen Sam
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