Antibody-mediated reduction of .alpha.-ketoamides

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Catalytic antibody

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435128, 435129, 5303889, C12P 1302

Patent

active

057632499

ABSTRACT:
Monoclonal antibodies raised against a 4-nitrophenyl phosphonate hapten catalyze the stereospecific reduction of an .alpha.-ketoamide to the corresponding .alpha.-hydroxyamide in the presence of an appropriate reducing agent.

REFERENCES:
patent: 4659567 (1987-04-01), Tramontano et al.
patent: 4888281 (1989-12-01), Schochetman et al.

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