Antibody-mediated cofactor-driven reactions

Details Antibody-mediated cofactor-driven reactions Antibody-mediated cofactor-driven reactions

1990-07-17

1993-06-15

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

435119, 4351885, 435189, C12P 100, C12P 1718, C12N 900

Patent

active

052197328

ABSTRACT:
Chemical reactions capable of being rate-enhanced by auxiliary species which interact with the reactants but do not become chemically bound to them in the formation of the final product are performed in the presence of antibodies which promote the reactions. The antibodies contain regions within their antigen binding sites which recognize the auxiliary species in a conformation which promotes the reaction. The antigen binding site frequently recognizes a particular transition state complex or other high energy complex along the reaction coordinate, thereby promoting the progress of the reaction along the desired route as opposed to other less favorable routes. Various classes of reaction together with appropriate antigen binding site specificities tailored for each are disclosed.

REFERENCES:
Shokat, K. M., et al, (1988) Angew. Chem. Int. Ed. Engl. 27 (9), 1172-1174.
Iverson, B. L., et al, (1989) Science 243, 1184-1188.
Blackburn, G. M. et al, (1989) Biochem J. 262, 381-390.

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