Antibody-mediated and ligand-mediated targeting of differentiati

Details Antibody-mediated and ligand-mediated targeting of differentiati Antibody-mediated and ligand-mediated targeting of differentiati

1991-07-12

1993-07-27

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424 858, 514 21, 436829, A61K 3722, A61K 966

Patent

active

052309002

ABSTRACT:
The present invention relates to compositions which mediate antibody and ligand targeting of differentiation-inducers to tumor cells and methods for employing the same.

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Kapil Mehta et al, "Induction of Tissue Transglutaminase in Human Peripheral Blood Monocytes by Intracellular Delivery of Retinoids", Journal of Leukocyte Biology, 41:341-348 (1987).
The Merck Index, 10th Ed., (Merck & Co., Inc., Rayway, N.J., 1983) p. 1057.
Otaka et al., "Antibody-Mediated Targeting of Differentiation Inducers to Tumor Cells: Inhibition of Colonic Cancer Cell Growth In Vitro and In Vivo", Biochemical and Biophysical Research Communications, vol. 158, No. 1, Jan. 16, 1989, pp. 202-208.

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