Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-04-04
2006-04-04
Harris, Alana M. (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S350000, C530S385000, C530S386000, C530S387100, C530S387900, C530S388800, C530S388850, C530S388150, C530S389100, C530S300000
Reexamination Certificate
active
07022821
ABSTRACT:
The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell. The present invention further provides for methods of inhibiting TADG-15 expression and/or protease activity, methods of detecting TADG-15 mRNA and/or protein and methods of screening for TADG-15 inhibitors. Additionally, the present invention provides for cell-specific targeting via TADG-15 and methods of vaccinating an individual against TADG-15. The instant invention also includes a kit containing antibodies for the detection of TADG-15 protein. The methods described are useful in the diagnosis, treatment and prevention of cancer, particularly breast and ovarian cancer.
REFERENCES:
patent: 5972616 (1999-10-01), O'Brien
patent: 09149790 (1997-06-01), None
Amino acid database, Accession #W22987, 1997.
Lerner, Tapping the immunological repertoire to produce antibodies of predetermined specificity. Nature 229:592-596, 1982.
Lin et al. Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity. The Journal of Biological Chemistry 274(26):18231-18236, Jun. 25, 1999.
Database alignment, sequence comparison between Applicants' SEQ ID No.: 2 and Lin's sequence, 2001.
Roitt, Ivan M. et al. Immunology, Third Edition, pp. 6.4 and 6.5, 1993. Publisher Mosby.
English translation of Japanese document, J0149790-A, Jun. 1997.
Harlow and Lane. Antibodies, A Laboratory Manual, pp. 319, 321-325 and 340-352, 1988.
O'Brien Timothy J.
Tanimoto Hirotoshi
Alder Benjamin Aaron
Harris Alana M.
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