Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Patent
1994-12-29
2000-01-04
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
435332, 435334, 53038875, 5303911, 530405, 5303873, C12N 500, C12N 502, C07K 1600, C12P 2108
Patent
active
060109025
ABSTRACT:
The present invention relates to novel antibody heteroconjugates and bispecific antibodies and methods and compositions and their use in the enhancement or inhibition of activation and function of T or B lymphocytes. The heteroconjugates are comprised of at least two antibody molecules cross-linked to each other, each molecule being reactive with a different lymphocyte antigen on the same cell. The invention also provides bispecific antibodies comprising a first binding region reactive with an antigen on a lymphocyte and a second binding region reactive with a different antigen on the lymphocyte. The heteroconjugates, bispecific antibodies, methods and compositions of this invention are therefore useful in the regulation of lymphocyte function, resulting in the improvement of cellular immune responses in various disease states.
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Kunfer et al., "Cocluste
Gilliland Lisa K.
Ledbetter Jeffrey A.
Bristol-Meyers Squibb Company
Huff Sheela J.
Scheiner Toni R.
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