Antibody fusion proteins: effective adjuvants of protein...

Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S134100, C424S156100, C424S277100, C435S372000, C530S387300

Reexamination Certificate

active

07736652

ABSTRACT:
The present invention provides methods of use of various antibody-immunostimulant fusion proteins as adjuvants of antigenic protein vaccinations to elicit humoral and/or cellular immune responses in vaccinated subjects. Compositions which include these fusion proteins and innate and/or exogenous antigenic proteins are also provided.

REFERENCES:
patent: 5650150 (1997-07-01), Gillies
patent: 5977322 (1999-11-01), Marks et al.
patent: 6194177 (2001-02-01), Campbell et al.
patent: 6617135 (2003-09-01), Gillies et al.
patent: 2004/0057969 (2004-03-01), Smith et al.
patent: WO 97/30089 (1997-08-01), None
Lustgarten et al, Jan. 1, 1999. The Journal of Immunology. 162(1):359-65.
Wu, 2002. Clinica Chimica Acta. 322: 11-19.
Lode et al, 2000. Drugs Today (Barc). 36(5): 321-336.
Bulfone-Paus et al (1998. Cancer Research. 58: 2707-2710).
Helguera et al, 2002, Clinical Immunology, 105(3): 233-246.
Dela Cruz et al, 2005, Vaccine 23: 4793-4803.
Wells (Sep. 18, 1990) Biochemistry 29(37): 8509-8517.
Ngo et al. (Mar. 2, 1995) “The Protein Folding Problem and Tertiary Structure Prediction, Chapter 14: Computational Complexity Protein Structure Prediction, and the Levinthal Paradox” pp. 492-495.
Bork (2000) Genome Research 10:398.
Skolnick and Fetrow (2000) Trends in Biotech. 18(1): 34.
Doerks et al. (Jun. 1998) Trends in Genetics 14(6): 248.
Smith and Zhang (Nov. 1997) Nature Biotechnology 15:1222.
Brenner (Apr. 1999) Trends in Genetics 15(4): 132.
Bork and Bairoch (Oct. 1996) Trends in Genetics 12(10): 425.
Larregina et al (1997. Immunology. 91: 303-313).
Dela Cruz et al (2006; Molecular Immunology; 43: 667-676).
Braun and Pantel (1998) “Prognostic significance of micrometastatic bone marrow involvement,”Breast Cancer Research and Treatment, 52:201-216.
Bowie et al. (1990) “Deciphering the message in protein sequences: tolerance to amino acids substitutions,”Science, 247:1306-1310.
Ngo et al. (1994) “Computational complexity, protein structure prediction, and the Levinthal paradox,”The Protein Folding Problem and Tertiary Structure Prediction, Merz et al., eds, Birkhauser, Boston, p. 433-506.
Pawelec (2004) “Tumour escape: antitumor effectors too much of a good thing?”Cancer lmmuunol. Imminother., 53:262-274.
Penichet et al. (1997) “Antibody-IL-2 fusion proteins: a novel strategy for immune potentiation,”Human Antibodies, 8(3):106-118.
Anselmino, et al., 1989 “Human basophils selectively express the Fc gamma RII (CDw32) subtype of IgG receptor”J Allergy Clin Immunol84:907-914.
Arai, et al., 1990 “Cytokines: coordinators of immune and inflammatory responses”Annu Rev Biochem59:783-836.
Baselga, et al., 1996 “Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2
eu-overexpressing metastatic breast cancer”J Clin Oncol14:737-744.
Becker et al., 1996 “An antibody-interleukin 2 fusion protein overcomes tumor heterogeneity by induction of a cellular immune response” Proc Natl Acad Sci USA 93:7826-7831.
Becker et al., 1996 “Long-lived and transferable tumor immunity in mice after targeted interleukin-2 therapy” J Clin Invest 98:2801-4.
Becker et al., 1996 “T cell-mediated eradication of murine metastatic melanoma induced by targeted interleukin 2 therapy” J Exp Med 183:2361-6.
Boyle, 1990, in Bacterial Immunoglobulin-Binding Proteins, ed. Boyle, M.P.D. (Academic, San Diego), vol. 1, pp. 17-28.
Brossart, P., et al., 2000 “Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells”Blood96:3102.
Buckle, et al., 1989 “The effect of IFN-gamma and colony-stimulating factors on the expression of neutrophil cell membrane receptors”J Immunol143:2295-2301.
Chen et al, 1998 “DNA vaccines encoding full-length or truncated Neu induce protective immunity against Neu-expressing mammary tumors” Cancer Res 58:1965-1971.
Chen, et al., 1995 “Monocyte-mediated lysis of acute myeloid leukemia cells in the presence of the bispecific antibody 251 x 22 (anti-CD33 x antiCD64)”Clin Cancer Res1:1319-1325.
Colombo et al. 1992 “Local Cytokine Availability Elicicts Tumor Rejection and Systemic Immunity through Granulocyte-T-Lymphocyte Cross-Talk,”Cancer Res52:4853-4857.
Dela Cruz et al., 2000 “Recombinant anti-human HER2
eu IgG3-(GMCSF) fusion protein retains antigen specificity, cytokine function and demonstrates anti-tumor activity”J Immunol165:5112-21.
Disis 1999, “Generation of immunity to the HER-2
eu oncogenic protein in patients with breast and ovarian cancer using a peptide-based vaccine”Clin Cancer Res5:1289-1297.
Disis, et al 2001 “Clinical translation of peptide-based vaccine trials: the HER-2
eu model”Crit Rev Immunol21:263-273.
Disis, et al. 1996 “Peptide-based, but not whole protein, vaccines elicit immunity to HER-2
eu, oncogenic self-protein”J Immunol156:3151-3158.
Disis, et al., 1998 “HER-2
eu oncogenic protein: issues in vaccine development”,Crit Rev Immunol18:37-45.
Disis, M. L., et al., 2001 “Cancer vaccines targeting the HER2
euoncogenic protein”Semin Oncol28:12-20.
Foy, et al. 2001 “Vaccination with Her-2
eu DNA or protein subunits protects against growth of a Her-2
eu-expressing murine tumor”Vaccine19:2598-2606.
Graille M., et al. 2000, “Crystal structure of aStaphylococcus aureusprotein A domain complexed with the Fab fragment of a human IgM antibody: structural basis for recognition of B-cell receptors and superantigen activity”Proc Natl Acad Sci USA97: 5399-5404.
Hartnell, et al., 1992 “IFN-gamma induces expression of Fc gamma RIII (CD16) on human eosinophils”J Immunol148:1471-1478.
Harvill et al., 1996 “In vivo properties of an IgG3-II-2 fusion protein. A general strategy for immune potentiation”J Immunol157:3165-70.
Hillson et al., 1993 “The structural basis of germline-encoded VH3 immunoglobulin binding to staphylococcal protein A”J Exp Med178:331-6.
Hiltbold et al., 2000, “The mechanism of unresponsiveness to circulating tumor antigen MUC1 is a block in intracellular sorting and processing by dendritic cells”J Immunol165:3730-41.
Hornick et al., 1997 “Chimeric CLL-1 antibody fusion proteins containing granulocyte-macrophage colony-stimulating factor or interleukin-2 with specificity for B-cell malignancies exhibit enhanced effector functions while retaining tumor targeting properties”Blood89:4437.
Johnson, et al. “Superantigens in human disease”Scientific AmericanApr. 1992, p. 92-101.
Klebanoff, et al., 1992 “Effects of gamma-interferon on human neutrophils: protection from deterioration on storage”Blood80:225-234.
Lachman, et al. 2001 “DNA vaccination against neu reduces breast cancer incidence and metastasis in mice”Cancer Gene Ther8:259-268.
Liu et al., 1998 “Treatment of B-cell lymphoma with chimeric IgG and single-chain Fv antibody-interleukin-2 fusion proteins”Blood92:2103-2112.
Meininger et al. 2000 “Characterization of the binding interface between the E-domain of Staphylococcal protein A and an antibody Fv-fragment”Biochemistry39: 26-36.
Mire-Sluis, 1993 “Cytokines and disease,”TIBTECH11:74-77.
Murray, et al., 2000 “Clinical trials of HER-2
eu-specific vaccines”Semin Oncol27:71-75.
Nagata, et al. 1997 “Peptides derived from a wild-type murine proto-oncogene c-erbB-2? HER2
eucan induce CTL and tumor suppression in syngeneic hosts”J Immunol159:1336.
Peng et al., 1999, “A single-chain IL-12 IgG3 antibody fusion protein retains antibody specificity and IL-12 bioactivity and demonstrates antitumor activity”J Immunol163:250-8.
Penichet et al., 1998 “An IgG3-IL-2 fusion protein recognizing a murine B cell lymphoma exhibits effective tumor

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antibody fusion proteins: effective adjuvants of protein... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibody fusion proteins: effective adjuvants of protein..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibody fusion proteins: effective adjuvants of protein... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4242700

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.