Antibody fragments to JTT-1 protein and cells secreting such...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S134100, C435S069600, C435S070100, C530S387300

Reexamination Certificate

active

10704030

ABSTRACT:
Novel cell surface molecules recognized by monoclonal antibodies against a cell surface molecule of lymphocytic cells that play an important role in autoimmune diseases and allergic diseases have been isolated, identified, and analyzed for their functions. The cell surface molecules are expressed specifically in thymocytes, lymphocytes activated by ConA-stimulation, and peripheral blood lymphocytes, and induce cell adhesion. Antibodies against the cell surface molecules significantly ameliorate pathological conditions of autoimmune diseases and allergic diseases.

REFERENCES:
patent: 5484892 (1996-01-01), Tedder et al.
patent: 5506126 (1996-04-01), Seed et al.
patent: 5521288 (1996-05-01), Linsley et al.
patent: 5770197 (1998-06-01), Linsley et al.
patent: 5914112 (1999-06-01), Bednar et al.
patent: 6075181 (2000-06-01), Kucherlapati et al.
patent: 2002/0164697 (2002-11-01), Coyle et al.
patent: 2002/0177191 (2002-11-01), Kroczek
patent: 2002/0182667 (2002-12-01), Kroczek
patent: 13320/99 (1999-04-01), None
patent: 19821060 (1999-04-01), None
patent: 0 984 023 (2000-03-01), None
patent: 1 125 585 (2001-08-01), None
patent: 11-228442 (1999-08-01), None
patent: 2000-154151 (2000-06-01), None
patent: WO95/33770 (1995-12-01), None
patent: WO97/26912 (1997-07-01), None
patent: WO98/11909 (1998-03-01), None
patent: WO98/19706 (1998-05-01), None
patent: WO98/37415 (1998-08-01), None
patent: WO98/38216 (1998-09-01), None
patent: WO98/45331 (1998-10-01), None
patent: WO 00/19988 (2000-04-01), None
patent: WO 00/46240 (2000-08-01), None
patent: WO 00/67788 (2000-11-01), None
patent: WO 01/08700 (2001-02-01), None
patent: WO 01/12658 (2001-02-01), None
patent: WO 01/15732 (2001-03-01), None
patent: WO 01/18022 (2001-03-01), None
patent: WO 01/21796 (2001-03-01), None
patent: WO 01/32675 (2001-05-01), None
patent: WO 01/64704 (2001-09-01), None
patent: WO 01/87981 (2001-11-01), None
patent: WO 02/44364 (2002-06-01), None
patent: WO 02/070010 (2002-09-01), None
patent: WO 02/076504 (2002-10-01), None
Bensimon et al., “Human lupus anti-DNA autoantibodies undergo essentially primary V kappa gene rearrangements,” EMBO J. 13(13):2951-62 (1994).
Eljaschewitsch et al., “Identification of a novel activation antigen on human CD4+ T cells,” IMMUNOBIOL., 194(1-3):27 (1995).
Goni et al., “Structural and idiotypic characterization of the L chains of human IgM autoantibodies with different specificities,” J. Immunol. 142(9):3158-63 (1989).
Hutloff et al., “Identification and initial characterization of a novel T cell-specific cell surface activation antigen,” IMMUNOBIOL., 197(2-4):172 (1997).
Iiyama et al., “The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches,” Immunology Letters, In Press, Uncorrected Proof available online Apr. 11, 2003, http://www.sciencedirect.com/science/journal/01652478.
Nurieva et al., “Inducible costimulator is essential for collagen-induced arthritis,” J. Clin. Invest. 111(5):701-06 (2003).
Pech et al., “A large section of the gene locus encoding human immunoglobulin variable regions of the kappa type is duplicated,” J. Mol Biol. 183(3):291-9 (1985).
Tomlinson et al., “The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops,” J. Mol. Biol. 227(3):776-98 (1992).
Aicher et al., “Characterization of Human Inducible Costimulator Ligand Expression and Function,” J. IMMUNOL., 164(9):4689-4696 (2000).
Bajorath “A molecular model of inducible costimulator protein and three-dimensional analysis of its relation to the CD28 family of T cell-specific costimulatory receptors,” J. Mol. Model. 5:169-176 (1999).
Beier et al., “Induction, binding specificity and function of human ICOS,” Eur. J. Immunol., 30(12):3707-3717 (2000).
Brodie et al., “LICOS, a primordial costimulatory ligand?” Current Biology, 10(6):333-336 (2000).
Buonfiglio et al., “Characterization of a novel human surface molecule selectively expressed by mature thymocytes, activated T cells and subsets of T cell lymphomas,” Eur. J. Immunol., 29(9)2863-2874 (1999).
Buonfiglio et al. “The T cell activation molecule H4 and the CD28-like molecule ICOS are identical,” Eur. J. Immunol., 30:3463-3467 (2000).
Cameron “Recent advances in transgenic technology” Molecular Biotechnology 7:253-65 (1997).
Chambers, “The expanding world of co-stimulation: the two-signal model revisited,” Trends in Immunology, 22(4):217-223 (2001).
Cocks et al. “A novel receptor involved in T-cell activation,”NATURE, 376:260-263 (Jul. 20, 1995).
Coyle et al., “The CD28-Related Molecule ICOS Is Required for Effective T Cell-Dependent Immune Responses,” IMMUNITY, 13:95-105, (2000).
Dong et al., “Cutting Edge: Critical Role of Inducible Costimulator in Germinal Center Reactions,” J. Immunol., 166(6):3659-3662 (2001).
Dong, “ICOS co-stimulatory receptor is essential for T-cell activation and function,” NATURE 409(6816):97-101 (2001).
Goding, “Monoclonal Antibodies: Principles and Practice,” 2ndEdition, Academic Press, Orlando, Florida, Chapter 8, pp. 281-293 (1986).
Gonzalo et al., “The Related Molecules CD28 and Inducible Costimulator Deliver Both Unique and Complementary Signals Required for Optimal T Cell Activation,” J. Immunol., 166(1):1-5 (2001).
Guo et al., “Stimulatory Effects of B7-Related Protein-1 on Cellular and Humoral Immune Responses in Mice,” J. Immunol., 166(9):5578-5584 (2001).
Harlow and Lane, “Antibodies: A Laboratory Manual,” Cold Spring Harbor Laboratory, p. 285 (1988).
Hanzawa et al., “Characteristics of a TTH1 antibody which blocks an unknown adhesion phenomenon,” Proceedings of the Japanese Society for Immunology, vol. 24, Abstract No. W17-13 (1994) [Original Japanese and English Language Translation].
Heyeck et al. “Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk,” Proc. Natl. Acad. Sci. USA, vol. 90, pp. 669-673 (1993).
Houdebine “Production of pharmaceutical proteins from transgenic animals” J. Biotechnol. 34:269-87 (1994).
Hutloff et al. “ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28,” NATURE 397:263-266 (1999).
Ishikawa et al., “Prediction of the Coding Sequences of Unidentified Human Genes. X. The Complete Sequences of 100 New cDNA Clones from Brain Which Can Code for Large Proteins in vitro,” DNA Research, 5:169-176 (1998).
Kappel et al. “Regulating gene expression in transgenic animals” Current Opinion in Biotechnology 3:548-53 (1992).
Kopf et al., “Inducible Costimulator Protein (ICOS) Controls T Helper Cell Subset Polarization after Virus and Parasite Infection,” J. Exp. Med., 192(1):53-61 (2000).
Kuchroo et al. “B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy,” CELL, 80:707-718 (Mar. 10, 1995).
Ling et al., “Identification of GL50, a Novel B7-Like Protein That Functionally Binds to ICOS Receptor,” J. Immunol., 164(4):1653-1657 (2000).
Mages et al. “Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand,” Eur. J. Immunol. 30:1040-1047 (2000).
Marguet et al. “cDNA Cloning for Mouse Thymocyte-activating Molecule,” The Journal of Biological Chemistry, vol. 267, No. 4, pp. 2200-2208 (1992).
McAdam, “ICOS is critical for CD40-mediated antibody class switching,” NATURE 409(6816):102-105 (2001).
McAdam, “Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+T Cells,” J. IMMUNOL., 165(9):5035-5040 (2000).
McAda

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antibody fragments to JTT-1 protein and cells secreting such... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibody fragments to JTT-1 protein and cells secreting such..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibody fragments to JTT-1 protein and cells secreting such... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3902574

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.