Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1997-03-06
2000-05-23
Reeves, Julie
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303877, 5303888, 53038822, 4241331, 4241551, 4241431, 435 696, 435 697, 435328, 435471, A61K 39395, C12P 2104
Patent
active
060667192
ABSTRACT:
This invention describes the production of bivalent linear F(ab').sub.2 fragments comprising tandem repeats of a heavy chain fragment V.sub.H -C.sub.H 1-V.sub.H -C.sub.H 1 cosecreted with two light chains, so as to form two functional antigen binding sites, wherein both the C-terminus of the first C.sub.H 1 is directly joined by a peptide bond to the N-terminus of the second V.sub.H.
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Genetech, Inc.
Lee Wendy M.
Reeves Julie
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