Antibody fragment capable of modulating multidrug resistance...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C530S387700, C530S387900

Reexamination Certificate

active

10405123

ABSTRACT:
An antibody fragment and methods of utilizing same are provided. The antibody fragment includes an antigen binding region capable of binding an extracellular portion of a P-glycoprotein thereby at least partially inhibiting drug efflux activity in multidrug resistant cells.

REFERENCES:
patent: 3791932 (1974-02-01), Schuurs et al.
patent: 3839153 (1974-10-01), Schuurs et al.
patent: 3850752 (1974-11-01), Schuurs et al.
patent: 3853987 (1974-12-01), Dreyer
patent: 3867517 (1975-02-01), Ling
patent: 3879517 (1975-04-01), Meyn et al.
patent: 3901654 (1975-08-01), Gross
patent: 3935074 (1976-01-01), Rubenstein et al.
patent: 3984533 (1976-10-01), Uzgiris
patent: 3996345 (1976-12-01), Ullman et al.
patent: 4034074 (1977-07-01), Miles
patent: 4098876 (1978-07-01), Piasio et al.
patent: 4666828 (1987-05-01), Gusella
patent: 4683202 (1987-07-01), Mullis
patent: 4801531 (1989-01-01), Frossard
patent: 4837306 (1989-06-01), Ling et al.
patent: 4866042 (1989-09-01), Neuwelt
patent: 4879219 (1989-11-01), Wands et al.
patent: 5011771 (1991-04-01), Bellet
patent: 5192659 (1993-03-01), Simons
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5272057 (1993-12-01), Smulson et al.
patent: 5281521 (1994-01-01), Trojanowski
patent: 5403484 (1995-04-01), Ladner et al.
patent: 5403574 (1995-04-01), Piwnica-Worms
patent: 5427908 (1995-06-01), Dower et al.
patent: 5434075 (1995-07-01), Mechetner et al.
patent: 5464764 (1995-11-01), Capecchi
patent: 5487992 (1996-01-01), Capecchi
patent: 5516637 (1996-05-01), Huang et al.
patent: 5543423 (1996-08-01), Zelle et al.
patent: 5556856 (1996-09-01), Engel et al.
patent: 5571698 (1996-11-01), Ladner et al.
patent: 5580717 (1996-12-01), Dower et al.
patent: 5658727 (1997-08-01), Barbas et al.
patent: 5698426 (1997-12-01), Huse
patent: 5733743 (1998-03-01), Johnson et al.
patent: 5750753 (1998-05-01), Kimae et al.
patent: 5766946 (1998-06-01), Cianfriglia
patent: 5780225 (1998-07-01), Wigler et al.
patent: 5821047 (1998-10-01), Garrard et al.
patent: 5932447 (1999-08-01), Siegall
patent: 5969108 (1999-10-01), McCafferty et al.
patent: 6479639 (2002-11-01), Metchetner et al.
patent: 94/10198 (1994-05-01), None
Mayforth Designing Antibodies, Academic Press p. 106-107 (1993).
Niv et al Int. J. Cancer vol. 94 p. 864-872 (2001).
Roninson et al. “Amplification Of Specific DNA Sequences Correlates With Multi-Drug Resistance in Chineses Hamster Cells”, Nature, 309: 626-628, 1984.
Goldstein et al. “Expression of a Multidrug Resistance Gene in Human Cancers”, Journal of the National Cancer Institute, 81: 116-124, 1989.
Tsuruo et al. “Overcoming of Vincristine Resistance in P388 Leukemia In Vivo and In Vitro Through Enhanced Cytotoxicity of Vincristine and Vinblastine by Verapamil”, Cancer Res., 41: 1967-1972, 1981.
Hamada et al. “Functional Role for the 170- to 180-kDa Glycoprotein Specific to Drug-Resistant Tumor Cells as Revealed By Monoclonal Antibodies”, Proc. Natl. Acad. Sci. USA, 83: 7785-7789, 1986.
Jain “Delivery of Molecular Medicine to Solid Tumors”, Science, 271:1079-1080, 1996.
Huston et al. “Protein Engineering of Antibody Binding Sites: Recovery of Specific Activity in an Anti-Digoxin Single-Chain Fv. Analogue Produced inEscherichia coli.”, Proc. Natl. Acad. Sci. USA 85: 5879-5883, 1996.
Hoogenboom et al. “Multi-Subunit Proteins On The Surface Of Filamentous Phage: Methodologies For Displaying Antibody (Fab) Heavy And Light Chains”,Nucleic Acids Research, 19(15): 4133-4137, 1991.
Eva et al. “Cellular Genes Analogous to Retroviral onc Genes are Transcribed in Human Tumour Cells”, Nature, 295: 116-119, 1982.
Denkberg et al. “Direct Visualization of Distinct T Cell Epitopes Derived from a Melanoma Tumor-Associated Antigen by Using Human Recombiant Antibodies with MHC-Restricted T Cell Receptor-Like Specificity”, Proc. Natl. Acad. Sci., 99(14): 9421-9426, 2002.
Akiyama et al. “Isolation and Genetic Characterization of Human KB Cell Lines Resistant to Multiple Drugs”, Somaic Cell and Molecular Genetics 11(2): 117-126, 1985.
Sharma et al. “A Phenotype Conferring Selective Resistance to Lipophilic Antifolates in Chinese Hamster Oval Cells”, Cancer Res., 51: 2949-2959, 1991.
Brisson et al. “Expresion Of A Bacterial Gene In Plants By Using A Viral Vector”, Nature, 310:511-514, 1984.
Brogli et al. “Light-Regulated Expression Of A Pea Ribulose-1,5-Bisphosphate Carboxylase Small Subunit Gene In Transformed Plant Cells”, Science, 224 :838-843, 1984.
Cinciarelli et al. “Characterization By Somatic Cell Genetics Of A Monoclonal Antibody To The MDR1 Gene Product (P-Glycoprotein): Determination Of P-Glycoprotein Expression In Multi-Drug-Resistant KB And CEM Cell Variants”, Int. J. Cancer, 47:533-543, 1991.
Clackson et al., “Making Antibody Fragments using Phage Display Libraries”, Nature, 352: 624-628, 1991.
Cole et al. “Pharmcological Characterization Of Multidrug Resistant MRP-Transfected Human T%umor Cells”, Cancer Research, 54: 5902-5910, 1994.
Gurley et al. “Upstream Sequences Required For Efficient Expression Of A Soybean Heat shock Gene”. Molecular and Cellular Biology, 6(2): 559-565, 1986.
Hamada et al. “Mouse-Human Chimeric Antibody Against The Multidrug Transporter P-Glycoprotein”, Cancer Research, 50: 3167-3171, 1990.
Lej et al. “Charcterization Of The Erwinia Carotovora PelB Gene And Its Product Pectate Lyase”, Journal of Bacteriology, 169(9): 4379-4383, 1987.
Meyers et al. “Characterization Of Monoclonal Antibodies Recognizing A Mr 180,000 P-Glycoprotein: Differntial Expression Of the Mr 180,000 and Mr170,000 P-Glycoproteins In Multidrug-Resistant Human Tumor Cells”, Cancer Research, 49:3209-3214, 1989.
Pearson et al. “Reversal Of Drug Resistance In A Human Colon Cancer Xenograft Expressionb MDR1 Complementary DNA By In Vivo Administation Of MRK-16 Monoclonal Antibody”, Journal of the National Cancer Institute, 83(19):1386-1391, 1991.
Takamutsu et al. “Expression Of Bacterial Chloramphenicol Acetyltransferase Gene In Tobacco Plants Mediated By TMV-RNA”, EMBO Journal, 6(2): 307-311, 1987.
Coruzzi et al. “Tissue-Specific And Light-Regulated Expression Of A Pea Nuclear Gene Encoding The Small Subunit of Ribulose-1,5-Bisphosphate Carboxylase”, EMBO Journal; 3(8):1671-1680, 1984.
von Heijne “Signal Sequences The Limits Of Variation”,Journal of Molecular Biology, 184: 99-105, 1985.
Yakota et al. “Rapid Tumor Penetration Of A Single-Chain Fv And Comparison With Other Immunoglobulin Forms”, Cancer Res., 52:3402-3408, 1992.

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