Antibody for ligand capture assay

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C530S388300, C530S388500, C530S388400, C530S388800, C435S005000, C436S518000

Reexamination Certificate

active

07060799

ABSTRACT:
The present invention provides a novel method for the identification and clonal isolation of antibodies that bind to unique epitopes. The method is based on the use of antibodies as solid phase capture reagents to bind a known capture antibody epitope, thereby precluding the capture antibody epitope from being presented to a population of antibodies to be screened. The method is particularly suited for screening libraries of cloned antibodies, such as phage display combinatorial antibodies. An antibody specific for herpes simplex virus (HSV), was employed as a model for the assay.

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patent: 6156313 (2000-12-01), Burton et al.
Burioni et al., Recombinant human Fab to glycoprotein D neutralizes infectivity and prevents cell-to-cell transmission of herpes simplex viruses 1 and 2 in vitro. Proc. Natl. Acad. Sci. 91:355-359, Jan. 1994.
Odell et al., “Two Monoclonal Antibody “Sandwich”-Type Assay of Human Lutropin, with No Cross Reaction with Choriogonadotropin”,Clin. Chem., 33/9:1603-1607, 1987.
Williamson et al., “Human monoclonal antibodies against a plethora of viral pathogens from single combinatorial libraries”,Proc. Natl. Acad. Sci. USA, 90:4141-4145, 1993.

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