Antibody-enhanced stereospecific hydrolyses

Details Antibody-enhanced stereospecific hydrolyses Antibody-enhanced stereospecific hydrolyses

1992-12-11

1994-03-29

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435108, 435128, 435135, 4351885, 435280, C12P 1300, C12P 762

Patent

active

052984095

ABSTRACT:
Hydrolyses of various chiral compounds are performed in stereospecific manner by antibodies generated from analogs of transition states of the compounds. The compounds susceptible to such hydrolysis include esters, thioesters and amides. In certain embodiments of the invention, antibodi

REFERENCES:
patent: 4888281 (1989-12-01), Schochetman et al.
patent: 4900674 (1990-02-01), Benkovic et al.
Lerner, R. A., et al., "Principles of Antibody Catalysis", BioEssays 9:102-112 (Oct. 1988).
Massey, R. J., "Catalytic antibodies catching on," Nature 328(6129):457-458 (Jul. 30, 1987).
Webster's II New Riverside University Dictionary, "enzyme," p. 437 (1984).
Hackh's Chemical Dictionary, "enzyme(s)," p. 242 (1969).
Janda, K. D., et al., "Catalytic Antibodies with Lipase Activity and R or S Substrate Selectivity," Science 244:437-440 (Apr. 28, 1989).
Benkovic, S. J., et al., "Catalysis of a stereospecific bimolecular amide synthesis by an antibody," Proc. Natl. Acad. Sci. USA 85:5355-5358 (Aug. 1988).
Pollack, S. J., et al., "Stereospecific Hydrolysis of Alkyl Esters by Antibodies," J. Am. Chem. Soc. 111:5961-5962 (1989).
Schultz, P. G., et al., "Catalytic Antibodies," Chemical and Engineering News, pp. 26-40 (May 28, 1990).
Nishino, N., et al., "Pseudomonas aeruginosa Elastase," J. Biol. Chem. 255(8):3482-3486 (1980).
Brown, J. M., et al., "Chemical asymmetric synthesis,"Nature 342:631-636 (Dec. 7, 1989).
Whitesides, G. M., et al., "Enzymes as Catalysts in Synthetic Organic Chemistry", Angew. Chem. Int. Ed. Engl. 24:617-638 (1985).
Pollack, S. J., et al., "Selective Chemical Catalysis by an Antibody," Science 234:1570-1573 (Dec. 19, 1986).
Jacobs, J., et al., "Catalytic Antibodies," J. Am. Chem. Soc. 109(7):2174-2176 (1987).
Tramontano, A., et al., "Catalytic Antibodies", Science 234:1566-1569 (Dec. 19, 1986).
Cochran, A. G., et al., "Photosensitized Cleavage of a Thymine Dimer by an Antibody," J. Am. Chem. Soc. 110:7888-7890 (1988).
Shokat, K. M., et al., "A new strategy for the generation of catalytic antibodies," Nature 338:269-271 (Mar. 16, 1989).
Shokat, K. M., et al., Angew. Chem., Int. Ed. Engl. 100:1227-1229 (1988).
Iverson, B. L., et al., "Sequence Specific Peptide Cleavage Catalyzed by an Antibody," Science 243:1184-1188 (Mar. 3, 1989).
Pollack, S. J., et al., "Introduction of Nucleophiles and Spectroscopic Probes into Antibody Combining Sites", Science 242:1038-1040 (Nov. 18, 1988).
Pollack, S. J., et al., "A Semisynthetic Catalytic Antibody," J. Am. chem. Soc. 111:1929-1931 (1989).
Napper, A. D., et al., "A Stereospecific Cyclization Catalyzed by an Antibody," Science 237:1041-1043 (Aug. 28, 1987).
Jackson, D. Y., et al., "An Antibody-Catalyzed Claisen Rearrangement," J. Am. Chem. Soc. 110:4841-4842 (1988).
Hilvert, D., et al., "Catalysis of concerted reactions by antibodies: The Claisen rearrangement," Proc. Natl. Acad. Sci. USA 85:4953-4955 (Jul. 1988).
Schechter, I., et al., "Preferential Formation of Antibodies Specific toward D-Amino Acid Residues upon Immunization with Poly-DL-peptidyl Proteins," Biochemistry 6(3):897-905 (Mar. 1967).

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