Antibody-enhanced chemiluminescence reactions

Details Antibody-enhanced chemiluminescence reactions Antibody-enhanced chemiluminescence reactions

1992-04-10

1994-04-12

Nucker, Christine M.

Chemistry: analytical and immunological testing

Involving immune complex formed in liquid phase

Signal modification or steric inhibition

436513, 4351885, 435968, 5303889, 5303898, G01N 33542, G01N 33563, C07K 1506

Patent

active

053025334

ABSTRACT:
A method of increasing the light output from a chemiluminescent reaction of a dihydrophthalazinedione (DPD), and an oxidant, which comprises carrying out said reaction in the presence of at least one antibody, raised against an intermediate species of said chemiluminescent reaction.

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Shultz et al. C&EN, May 28, 1990.
Kricka et al.; Chapter 6, pp. 77-98, from handbook by CRC, Luminescence Immunoassay, CRC Press, 1990.
Brundett et al.; "Yields of Chemically Excited States" J. Am Chem Soc; 94:21, Oct. 18, 1972, pp. 7536-7541.
Kohen et al; "An assay for urinary estriol &-glucuronide-" Steriods; vol. 36(4), Oct. 1980 pp. 405-419.

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