Antibody-drug conjugates

Details Antibody-drug conjugates Antibody-drug conjugates

1988-11-10

1991-04-23

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530391, 530389, 530405, 530408, C07K 1528, C07K 1706

Patent

active

050101765

ABSTRACT:
Modified antibodies or antigen-recognizing fragments are prepared with a linker consisting of a malonate, wherein the antibody or fragment thereof is attached through a carbonyl to an ester or amide group on one of the malonate carboxyls, and the drug is linked through a methylene to the 2-position carbon of the malonate.

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James W. Goding, Monoclonal Antibodies: Principles and Practice, Academic Press, San Diego, pp. 135-138, 1986.
Ghose et al., CRC Critical Rev. in Therapeutic Drug Carrier Systems, 3, 263-359, (1987).
Blair and Ghose, J. Immunol. Methods, 59, 129-43, (1983).
Ghose et al., Methods Enzymol., 93, 280-333, (1983).
Shen et al., Biochem. Biophys. Res. Comm., 102, 1048-54, (1981).
Singh et al., J. Heterocyclic Chem., 19, 1581-82, (1982).
King et al., Biochem., 25, 5774-79, (1986).

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