Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1993-03-30
1996-09-17
Achutamurthy, Ponnathapura
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
4241811, 5303911, 536 64, A61K 39395, A61K 3944
Patent
active
055566235
ABSTRACT:
Immunoconjugates of antibodies or antigen-recognizing fragments of antibodies and monovalent cytotoxic drug derivatives make use of .beta.-alanine derived linkers wherein the antibody or fragment thereof is attached to the linker's carboxy group via an ester or amide group and the drug is attached through the linker's 2-position methylene group. Intermediates, compositions and methods of use also are provided.
REFERENCES:
patent: 5010176 (1991-04-01), Barton
patent: 5028697 (1991-07-01), Johnson et al.
patent: 5030620 (1991-07-01), Hannart et al.
patent: 5045451 (1991-09-01), Uhr et al.
patent: 5106951 (1992-04-01), Morgan et al.
patent: 5122368 (1992-06-01), Greenfield et al.
Borrebaeck, Journal of Immunological Methods, vol. 123 pp. 157-165 (1989).
Waldmann, Science, vol. 252, pp. 1657-1662 (1991).
Spalding, Bio/Technology, vol. 11, pp. 428-429 (1993).
Hermentin et al., Behring Inst. Mitt, No. 82, pp. 197-215 (1988).
Osband et al., Immunology Today, vol. 11, No. 6, pp. 193-195 (1990).
Harris et al., TIBTECH, vol. 11, pp. 42-44 (1993).
Barton Russell L.
Guttman-Carlisle Deborah L.
Koppel Gary A.
Achutamurthy Ponnathapura
Blalock Donna K.
Eli Lilly and Company
Gaylo Paul J.
LandOfFree
Antibody-drug conjugates does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibody-drug conjugates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibody-drug conjugates will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-411607