Antibody-drug conjugates

Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...

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4241811, 5303911, 536 64, A61K 39395, A61K 3944

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active

055566235

ABSTRACT:
Immunoconjugates of antibodies or antigen-recognizing fragments of antibodies and monovalent cytotoxic drug derivatives make use of .beta.-alanine derived linkers wherein the antibody or fragment thereof is attached to the linker's carboxy group via an ester or amide group and the drug is attached through the linker's 2-position methylene group. Intermediates, compositions and methods of use also are provided.

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Hermentin et al., Behring Inst. Mitt, No. 82, pp. 197-215 (1988).
Osband et al., Immunology Today, vol. 11, No. 6, pp. 193-195 (1990).
Harris et al., TIBTECH, vol. 11, pp. 42-44 (1993).

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