Antibody drug-conjugates

Details Antibody drug-conjugates Antibody drug-conjugates

1996-05-17

1997-09-09

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

4241811, 5303919, 536 64, 540478, A61K 39395, A61K 3944

Patent

active

056653581

ABSTRACT:
Immunoconjugates of antibodies or antigen-recognizing fragments of antibodies and monovalent cytotoxic drug derivatives make use of .beta.-alanine derived linkers wherein the antibody or fragment thereof is attached to the linker's carboxy group via an ester or amide group and the drug is attached through the linker's 2-position methylene group. Intermediates, compositions and methods of use also are provided.

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