Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-04-19
2011-04-19
Harris, Alana M (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S004000, C435S007210, C435S007230, C435S007920, C435S007940, C436S063000, C436S501000, C436S503000, C436S536000
Reexamination Certificate
active
07927814
ABSTRACT:
Disclosed is a novel method for determination of ProGRP which is free from problems such as the dispersion in the values of measurements and operational constraints such as handling of a test sample. A method for the determination of a gastrin-releasing peptide precursor or a digest thereof using at least two different antibodies each of which can recognize a peptide comprising the partial amino acid sequence starting from amino acid residue 40 and ended at amino acid residue 75 in the amino acid sequence depicted in SEQ ID NO:1; and a method for the determination of a gastrin-releasing peptide precursor and/or a digest thereof using at least two different antibodies each of which can recognize a peptide comprising the partial amino acid sequence starting from amino acid residue 40 and ended at amino acid residue 79 in the amino acid sequence depicted in SEQ ID NO:1. The methods have such advantages that a detection sensitivity comparable to that in a conventional determination method can be achieved, that it is easy to handle a sample after the sample is collected, and that a highly reproducible measurements can be obtained.
REFERENCES:
patent: 6504010 (2003-01-01), Wang et al.
patent: 0 811 683 (1997-12-01), None
patent: WO 03/097666 (2003-11-01), None
Miyake et al., Cancer Research, 54:2136-2140 (1994).
Kodama et al., The Journal of Medicine, 32(1):87-97 (1994).
Advanced Life Science Institute, Inc.
Corless Peter F.
Edwards Angell Palmer & & Dodge LLP
Harris Alana M
O'Day Christine C.
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