Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1996-09-09
2000-04-11
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
5303871, 530350, G01N 3353
Patent
active
060487011
ABSTRACT:
Antibodies directed to human protein mismatch repair proteins can be used diagnostically to discriminate between proliferating and non-proliferating cells. In addition, they can be used to determine whether cells have a mismatch repair defect caused by a mutation in e.g., hMSH2, hMLH1, or hPMS2. They can also be used to monitor the efficacy of anti-neoplastic therapies.
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Burrell Marilee
Hill David E.
Kinzler Kenneth W.
Leach Fredrick S.
Vogelstein Bert
Davis Minh-Tam
Hutzell Paula K.
The Johns Hopkins University
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