Antibody conjugates

Details Antibody conjugates Antibody conjugates

1985-06-07

1989-04-25

Terapane, John F.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 424 78, 424 858, 128 11, 530387, 525 541, 600 4, A61N 512, A61K 4902, A61K 3174, A61K 4202

Patent

active

048246590

ABSTRACT:
An antibody or antibody fragment is modified by chemical linkage to a synthetic poly(amide/urea/thiourea) which contains a plurality of boron atoms or other functional groups, conferring upon the resultant conjugate desirable properties as a diagnostic and/or therapeutic agent. In a preferred embodiment, boron-containing groups are conjugated to the antibody/fragment such that the resultant conjugate contains 50-2000 boron atoms, with about 96% Boron-10 isotope content, to produce conjugates useful for neutron-activated radiotherapy of tumors or pathological lesions.

REFERENCES:
patent: 4331647 (1982-05-01), Goldenberg
patent: 4348376 (1982-09-01), Goldenberg
patent: 4361544 (1982-11-01), Goldenberg
patent: 4434150 (1984-02-01), Azad et al.
patent: 4460559 (1984-07-01), Goldenberg
patent: 4460561 (1984-07-01), Goldenberg
patent: 4466952 (1984-08-01), Hadd
patent: 4665897 (1987-05-01), Lemelson
patent: 4674480 (1987-06-01), Lemelson

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