Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Reexamination Certificate
2008-04-01
2010-12-07
Kelly, Robert M (Department: 1633)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
C514S04400A
Reexamination Certificate
active
07846725
ABSTRACT:
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, wherein the expression of GDP-mannose 4,6-dehydrogenase is inhibited by RNA interference.
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paten
Hanai Nobuo
Hosaka Emi
Kanda Yutaka
Nakamura Kazuyasu
Satoh Mitsuo
Kelly Robert M
Kyowa Hakko Kirin Co., Ltd
Sughrue & Mion, PLLC
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