Antibody combining sites that exhibit stereoselective synthase a

Details Antibody combining sites that exhibit stereoselective synthase a Antibody combining sites that exhibit stereoselective synthase a

1987-08-07

1992-01-07

Weimar, Elizabeth C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435232, 435123, 530387, 530388, C12P 1706, C12N 988, C12N 900, C07K 1528

Patent

active

050791524

ABSTRACT:
A phosphorus-containing analog-ligand having a stereoconfiguration that substantially corresponds to the stereoconfiguration of an amide- or ester-forming transition state is used to induce production of receptor molecules whose antibody combining sites have stereospecific amide or ester synthase catalytic activity when reacted with a ligand containing (i) a carbonyl carbon atom and (ii) an amine or alcohol group that are structurally capable of forming a preselected stereoisomer of a carboxylic amide or ester.

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