Antibody combining sites that exhibit amide or ester synthase ac

Details Antibody combining sites that exhibit amide or ester synthase ac Antibody combining sites that exhibit amide or ester synthase ac

1987-05-28

1990-02-13

Huleatt, Jayme A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Lyase

435183, 435125, 530387, 530388, C12N 988, C12N 900, C12P 1706, C07K 1500

Patent

active

049006746

ABSTRACT:
A phosphorous-containing analog-ligand having a conformation that substantially corresponds to the conformation of an amide- or ester-forming transition state is used to induce production of receptor molecules whose antibody combining sites have amide or ester synthase catalytic activity when reacted with a ligand containing (i) a carbonyl carbon atom and (ii) an amine or alcohol group that are structurally capable of forming a preselected carboxylic amide or ester bond.

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