Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Resolution of optical isomers or purification of organic...
Reexamination Certificate
2000-10-06
2010-02-23
Ramirez, Delia M (Department: 1652)
Chemistry: molecular biology and microbiology
Process of utilizing an enzyme or micro-organism to destroy...
Resolution of optical isomers or purification of organic...
C435S188500, C435S148000
Reexamination Certificate
active
07666658
ABSTRACT:
Nine efficient aldolase antibodies were generated using hapten 2. This hapten combines, in a single molecule, structural components employed for reactive immunization with structural components employed for forming a transition state analog of the aldol reaction. Characterization of two of these antibodies reveals that they are highly proficient (up to 1000-fold better than any other antibody catalyst) and enantioselective catalysts for aldol and retro-aldol reactions and exhibit enantio- and diastereo-selectivities opposite that of antibody 38C2.
REFERENCES:
patent: 6210938 (2001-04-01), Barbas et al.
patent: 6294374 (2001-09-01), Sinha et al.
Barbas Carlos F.
Lerner Richard A.
Zhong Guofu
Meah Mohammad Younus
Olson & Cepuritis, Ltd.
Ramirez Delia M
The Scripps Research Institute
LandOfFree
Antibody catalysis of enantio- and diastereo-selective aldol... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibody catalysis of enantio- and diastereo-selective aldol..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibody catalysis of enantio- and diastereo-selective aldol... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4163808