Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1997-01-31
1998-07-07
Huff, Sheela
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
53038873, 435334, 4353431, 4351723, 4241431, 4241441, A61K 39395
Patent
active
057770840
ABSTRACT:
The invention relates to a monoclonal antibody specifically binding to the human FLT3/FLK2 receptor protein. The invention further relates to hybridoma cells producing such an antibody, as well as to a method for generation of such hybridoma cells. One example of such a monoclonal antibody is the antibody produced and released by hybridoma cells deposited under No. DSM 2248 at the German Collection of Microorganisms and Cell Cultures (DSMZ).
REFERENCES:
patent: 5376531 (1994-12-01), Anderson et al.
1) Osband, ME et al. Immunol. Today 11: 193-195, 1990.
2) Rosnet, O. et al. Leukemia, 10: 238-248, 1996.
3) Rose C. et al. Hybridoma 14(5): 453-459, 1995.
4) Lyman SD et al. Oncogene 8(4): 815-822, 1993.
5) Meierhoff, G. et al. Leukemia, 9: 1368-1372, 1995.
6) Schlom J. In: Mol. Foundation Oncology, S. Broder (ed.) pp. 95-134, 1991.
Bennett, J.M. et al., "Proposed Revised Criteria for the Classification of Acute Myeloid Leukemia"; Annals of Internal Medicine, vol. 103 No. 4, pp. 620-625 (1985).
Buhring, H.J. et al., "The Monoclonal Antibody 11G7 Recognizes a Novel Differentiation Antigen Expressed on Hemopoietic Precursor Cells", Hybridoma, vol. 10 No. 1; pp. 77-88 (1991).
Buhring, H.J. et. al., "Modulation of p145.sup.c-kit Function in Cells of Patients with Acute Myeloblastic Leukemia.sup.1 ", Cancer Research 53, pp. 4424-4431 (1993).
Hannun, C. et al., "Ligand for FLT3/FLK2 Receptor Tyrosine Kinase Regulates Growth of Haematopoietic Stem Cells and is Encoded by Variant RNAs", Letters to Nature, vol. 368, pp. 643-648 (1994).
Hirayama, F. et al., "The flt3 Ligand Supports Proliferation of Lymphohematopoietic Progenitors and Early B-Lymphoid Progenitors", Blood, vol. 85 No. 7, pp. 1762-1768 (1995).
Lyman, S.D. et al., Cloning of the Human Homologue of the Murine flt3 Ligand: A Growth Factor for Early Hematopoietic Progenitor Cells, Blood, vol. 83 No. 10, pp. 2795-2801 (1994).
Matthews, Wm. et al., "Receptor Tyrosine Kinase Specific to Hematopoietic Stem and Progenitor Cell-Enriched Populations", Cell, vol. 65, pp. 1143-1152 (1991).
Muench, M.O. et al., "FLK-2/FLT-3 Ligand Regulates the Growth of Early Myeloid Progenitors Isolated From Human Fetal Liver", Blood, vol. 85 No. 4, pp. 963-972 (1995).
Rosnert O. et al., "Human FLT3/FLK2 Receptor Tyrosine Kinase is Expressed at the Surface of Normal and Malignant Hematopoietic Cells", Leukemia, vol. 10, pp. 238-248 (1996).
Small, D. et al., "STK-1, the Human Homolog of Flk-2/Flt-3, is Selectively Expressed in DC43.sup.+ Human Bone Marrow Cells and Is Involved in the Proliferation of Early Progenitor/Stem Cells", Pro. Natl. Acad. Sci. USA, vol. 91, pp. 459-463 (1994).
Donnelly Oppenheimer W.
Eberhard-Karls-Universitat Tubingen
Hamrick Claude A. S.
Huff Sheela
Reeves Julie E.
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