Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...
Patent
1995-06-07
2000-02-15
Johnson, Nancy A.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to antibody or antibody fragment or immunoglobulin;...
424 91, 4241301, 4241371, 4241391, 4241521, 4241721, 4241781, 435 721, 5303879, 5303882, 53038822, 5303891, 5303913, C07K 1618, A61K 39395, G01N 3353
Patent
active
060249366
ABSTRACT:
The DNA encoding the cell surface receptor for thrombin has been cloned and sequenced. The availability of this DNA permits the recombinant production of thrombin receptor which can be produced at cell surfaces and is useful in assay systems both for the detection of thrombin and for the evaluation of candidate thrombin agonists and antagonists. Further, the elucidation of the structure of the thrombin receptor permits the design of agonist and antagonist compounds which are useful diagnostically and therapeutically. The availability of the thrombin receptor also permits production of antibodies specifically immunoreactive with the receptor per se or with specific regions thereof which are also useful diagnostically or therapeutically.
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Coughlin Shaun R.
Scarborough Robert M.
COR Therapeutics Inc.
Johnson Nancy A.
The Regents of the University of California
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