Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-04-05
2011-04-05
Gabel, Gailene R (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200, C435S007250, C435S007500, C435S325000, C435S372300, C436S523000, C436S526000, C436S538000, C436S064000, C436S177000
Reexamination Certificate
active
07919265
ABSTRACT:
A negative isolation method for separately isolating preparations of Th1 and Th2 helper lymphocytes from peripheral blood mononuclear cells involving the use of novel combinations of monoclonal antibodies to separately sequester specific Th1 and Th2 lymphocytes and contaminating leukocytes and erythrocytes, adding a magnetic colloid to the cells, and using a magnetic column for fractionation of Th1 and Th2 cells. Imbalances in the relative numbers of Th1 and Th2 lymphocytes can be used in the diagnosis and prognosis of human diseases.
REFERENCES:
patent: 6488930 (2002-12-01), Wu et al.
patent: 6913924 (2005-07-01), Blom et al.
patent: 2002/0081635 (2002-06-01), Thomas et al.
patent: 2006/0239962 (2006-10-01), Banchereau
Freishtat et al. NKG2A and CD56 Are Coexpressed on Activated Th2 but not Th1 Lymphocytes, Human Immunology 66: 1223-1234 (2005).
Robert J. Freishtat, M.D., MPH, et al. “NKG2A and CD56 Are Coexpressed on Activated TH2 but Not TH1 Lymphocytes”, Human Immunology 66, 1223-1234 (2005).
Blank Rome LLP
Children's Research Institute
Gabel Gailene R
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