Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1989-03-24
1992-06-23
Lacey, David L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530826, 424 89, C07K 1504, A61K 3912
Patent
active
051244403
ABSTRACT:
Glycopeptides of the gcI (gB) complex of human cytomegalovirus are disclosed. They possess unique B cell and T cell epitopes not present in other gcI glycopeptides. Glycopeptide fragments which comprise minimal antigenic determinants of the gcI complex are also disclosed, as are recombinant expression vectors, vaccines, and diagnostic methods.
REFERENCES:
Journal of General Virology, vol. 69, 1988, SGM (GB), D. R. Gretch et al.: "Characterization of a Human Cytomegalovirus Glycoprotein Complex (gCI)", pp. 1205-1215.
Virology, vol. 167, 1988, Academic Press, Inc., R. R. Spaete et al.: "Human Cytomegalovirus Strain Towne Glycoprotein B 1s Processed by Proteolytic Cleavage", pp. 207-225.
The EMBO Journal, vol. 5, No. 11, 1986, IRL Press Limited, (Oxford, GB), M. P. Cranage et al.: "Identification of the Human Cytomegalovirus Glyprotein B. Gene and Induction of Neutralizing Antibodies via its Expression in Recombinant Vaccinia Virus", pp. 3057-3063.
Journal Exp. Medicine, vol. 168, Sep. 1988, The Rockefeller University Press, L. K. Borysiewicz et al.: "Human Cytomegalovirus-Specific Cytotoxic T. Cells", pp. 919-931.
Gehrz Richard C.
Kari Bruce I.
Liu Yung-Nan
Stinski Mark F.
Guest Shelly J.
Lacey David L.
The Childrens Hospital, Inc.
University of Iowa Research Foundation
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